Abstract: Pheochromocytoma is a kind of benign tumor which can be cured by surgical resection. However, since catecholamine secreted by the tumor has the characteristic of circulating and the removal of the tumor can cause blood pressure fluctuations during the operation, which can lead to patients' bleeding. Perioperative preparation is quitely important for these patients. In this case, the patient reported not only faced the problem that the huge tumor extruded nearby important organs such as liver and pancreas making the surgery extremely difficult with high bleeding risk, but also was RhD negative blood type, a rare blood type in China- meaning great troubles in blood preparation. Hopefully, the patient's tumor was successfully resected by using a variety of autologous blood methods combined with the application of allogenetic blood. The case can set an example for similar situations.