Role of serum multi-index combined detection in differential diagnosis and prognosis evaluation of breast cancer
-
摘要: 目的:血清肿瘤抗原153(CA153)、糖类抗原125(CA125)、癌胚抗原(CEA)、降钙素和铁蛋白等指标联合检测对乳腺癌的鉴别诊断和预后评估作用。方法:对2016-06—2018-06就诊的250例女性患者进行研究,根据研究对象健康状态与确诊疾病分为正常组、乳腺炎组、乳腺增生组、乳腺纤维瘤组、乳腺癌组,每组50例。检查5组患者年龄、乳房疾病史、文化程度、病理分期指标的差异和血清中的CA125、CA153、CEA、铁蛋白、降钙素,观察并比较这5项肿瘤标志物对5组患者中表达含量的统计学差异,应用回归分析方法分析各肿瘤标记物对乳腺癌患者疾病复发或疾病转移的综合影响。结果:5组患者年龄、乳房疾病史、文化程度、病理分期指标的差异无统计学意义(P＞0.05);通过对5组患者多项血清生化指标含量的比较,发现CA125、CA153、铁蛋白指标的差异有统计学意义(P＜0.05);由血清多项生化指标联合检测对乳腺癌组患者疾病复发和转移的评估作用可以看出,乳腺癌患者复发情况CA125、CA153、铁蛋白指标的差异有统计学意义(P＜0.05);转移情况患者CA125、CA153、CEA、铁蛋白指标的差异有统计学意义(P＜0.05)。结论:CA125、CA153、CEA、铁蛋白、降钙素联合检测可以提高对乳腺癌的鉴别诊断和预后评估的特异性和敏感性。Abstract: Objective:To investigate the role of combined detection of serum tumor antigen 153(CA153),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),calcitonin and ferritin indicators in the differential diagnosis and prognosis evaluation of breast cancer.Method:From June 2016 to June 2018,250 women admitted to Shaoguan First People's Hospital were divided into normal group,mastitis group,mammary gland hyperplasia group,mammary fibroids group and breast cancer group according to their health status and diagnosed diseases,with 50 cases in each group.Check the five group objects Age,breast disease history,education level,the pathological staging index and serum levels of CA125,CA153,CEA,ferritin and calcitonin of all patients were collected,the expression levels of the five tumor markers were compared,and the comprehensive effect of each tumor marker on breast cancer disease recurrence or metastasis was analyzed using regression analysis.Result:There was no statistically significant difference in age,breast disease history,education level and pathological staging of the five groups(P＞0.05).By comparing the contents of multiple serum biochemical indexes in the five groups,the differences of CA125,CA153 and ferritin in the five groups were statistically significant(P＜0.05).By multiple serum biochemical indexes combined detection of disease recurrence and metastasis in patients with breast cancer group,it can be seen that the differences of recurrence indexes CA125,CA153 and ferritin in patients with breast cancer were statistically significant(P＜0.05).The differences of CA125,CA153,CEA and ferritin in metastatic patients were statistically significant(P＜0.05).Conclusion:Combined detection of CA125,CA153,CEA,ferritin and calcitonin could improve the specificity and sensitivity of differential diagnosis and prognosis evaluation of breast cancer.
-
Key words:
- breast cancer /
- tumor markers /
- combined detection
-
-
[1] Györffy B,Bottai G,Fleischer T,et al.Aberrant DNA methylation impacts gene expression and prognosis in breast cancersubtypes[J].Int J Cancer,2016,138:87-97.
[2] Masood S.Breast cancer subtypes:morphologic and biologic characterization[J].Womens Health (Lond Engl),2016,12:103-119.
[3] Hein A,Lambrechts D,von Minckwitz G,et al.Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patientsreceiving bevacizumab:Results from the randomized phase III GeparQuinto study[J].Int J Cancer,2015,137:2981-2988.
[4] Sestak I,Cuzick J.Markers for the identification of late breast cancer recurrence[J].Breast Cancer Res,2015,17:516.
[5] 贾举闻,付峥,葛麟,等.血清半乳凝素-3、糖类抗原153和肿瘤特异生长因子结合乳腺钼靶X线对乳腺癌的早期诊断价值[J].中国肿瘤临床与康复,2017,24(2):135-138.
[6] Soady KJ,Kendrick H,Gao Q,et al.Mouse mammary stem cells express prognostic markers for triple-negative breastcancer[J].Breast Cancer Res,2015,17:31.
[7] 张美玲,董恒进.乳腺癌基因分型与血清肿瘤标志物表达的相关性分析[J].中国现代应用药学,2017,34(1):111-115.
[8] 王英,李佩章,黄玲莎,等.HE4和CA153联合表达在预测早期乳腺癌淋巴结转移中的意义[J].现代肿瘤医学,2017,25(3):390-392.
[9] 陈龙舟,唐静,刘娟,等.淋巴结阴性乳腺癌血清TRACP5b和CEA、CA-153在预测骨转移价值方面的对比研究[J].中国妇幼保健,2016,31(24):5278-5280.
[10] Dowling RJ,Niraula S,Chang MC,et al.Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer:a prospective window of opportunity neoadjuvant study[J].Breast Cancer Res,2015,17:32.
[11] Hongchao P,Zhilan P,Jiediao L,et al.Forkhead box C1 boosts triple-negative breast cancer metastasis through activating the transcription of chemokine receptor-4[J].Cancer Sci,2018,109:3794-3804.
[12] 杨泽安.CEA、CA125及CA153在乳腺癌中的检测价值[J].湖南师范大学学报(医学版),2016,13(3):83-85.
[13] Millis SZ,Gatalica Z,Winkler J,et al.Predictive Biomarker Profiling of>6000 Breast Cancer Patients Shows Heterogeneity in TNBC,With Treatment Implications[J].Clin Breast Cancer,2015,15:473-481.
[14] Danja S,Helena S,Theron J,et al.Receptor activator of nuclear factor kB ligand,osteoprotegerin,and risk of death following a breast cancer diagnosis:results from the EPIC cohort[J].BMC Cancer,2018,18:1010.[FL)]
-
计量
- 文章访问数: 416
- PDF下载数: 453
- 施引文献: 0
下载: