Abstract: Objective:To observe the clinical significance of transfusion of different components of platelets in the patients with clinical thrombocytopenic disease.Method:A total of 185 cases requiring platelet transfusion in our clinical departments from July 2017 to February 2019 were selected for group study.The effect of different platelet component transfusions on the efficacy of platelet transfusion and platelet antibody production for different thrombocytopenic diseases was statistically analyzed.Result:Comparison of transfusion efficiencies of different types of platelet components in 163 patients with different disease groups showed that the efficiency of transfusion of white apheresis platelets was higher than that of apheresis platelets transfusion,the difference was statistically significant(P＜0.05).The positive rate of platelet antibody in the transfusion of white apheresis platelets group was lower than that in the transfusion of apheresis platelet group,the difference was statistically significant(P＜0.05).Comparing the platelet antibody distribution in white cell-derived platelet transfusion group and apheresis platelet transfusion group,the results showed that for multiple platelets transfusion times,platelet antibodies were more likely to be produced in the apheresis platelet transfusion group than the white cell-derived platelet transfusion group.Conclusion:When clinical thrombocytopenic disease requires multiple platelet transfusion therapy,it may be recommended to use transfusion of white apheresis platelets and monitor platelet antibodies,effectively improve platelet transfusion efficiency,reduce platelet antibody production rate,and achieve safe and efficient blood resources use.