Analysis of HbA2 and serum ferritin expression and correlation in thalassemia patients with iron deficiency anemia based on hemoglobin screening
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摘要: 目的:探讨基于血红蛋白电泳筛查基础上,分析地中海贫血合并缺铁性贫血患者血红蛋白A2(HbA2)、血清铁蛋白(SF)的表达水平及两者之间的相关性,评价缺铁严重程度对HbA2表达水平的影响。方法:地中海贫血筛查的1 248例受检者为研究对象,采用血红蛋白电泳以及基因诊断进行诊断,确定地中海贫血患者186例(地中海贫血组),地中海贫血合并缺铁性贫血患者46例(合并贫血组),缺铁性贫血患者19例(缺铁性贫血组)。对各组HbA2、SF表达水平进行检测,并运用Spearman探讨其相关性。结果:3组HbA2水平差异无统计学意义(P＞0.05);血清SF水平差异有统计学意义(P＜0.05)。Spearman相关性分析,合并贫血组、地中海贫血组中HbA2水平与血清SF表达水平无相关性(P＞0.05);在缺铁性贫血组中,HbA2水平与血清SF表达水平表现为相关性(P＜0.05)。结论:地中海贫血合并缺铁性贫血患者其HbA2与血清SF之间无相关性,但缺铁程度会直接影响HbA2的表达水平,影响其诊断准确性。Abstract: Objective: To investigate the expression level of hemoglobin A2 (HbA2) and serum ferritin (SF) in patients with thalassemia and iron deficiency anemia,and evaluate the influence of the severity of iron deficiency on the expression level of HbA2.Method: A total of 1 248 cases of thalassemia screened in our hospital were taken as the research object.Hemoglobin electrophoresis and gene diagnosis were used for diagnosis.The expression levels of HbA2 and SF in each group were detected,and Spearman was used to explore the correlation.Result: There was no significant difference in HbA2 level among the three groups (P＞0.05); there was significant difference in SF level among the three groups (P＜0.05). Spearman correlation analysis showed that there was no correlation between HbA2 level and SF expression level in thalassemia group and thalassemia group (P＞0.05); in iron deficiency anemia group,there was a correlation between HbA2 level and SF expression level (P＜0.05). Conclusion: There is no correlation between HbA2 and SF in thalassemia patients with iron deficiency anemia,but the degree of iron deficiency would directly affect the expression level of HbA2 and the accuracy of diagnosis.
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Key words:
- thalassemia /
- iron deficiency anemia /
- hemoglobin electrophoresis /
- hemoglobin A2 /
- serum ferritin
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