骨髓增生异常综合征2011 NCCN诊疗指南解读

孙耘玉, 陈宝安, 丁家华, 等. 骨髓增生异常综合征2011 NCCN诊疗指南解读[J]. 临床血液学杂志, 2012, 25(3): 148-152. doi: 10.13201/j.issn.1004-2806.2012.02.007
引用本文: 孙耘玉, 陈宝安, 丁家华, 等. 骨髓增生异常综合征2011 NCCN诊疗指南解读[J]. 临床血液学杂志, 2012, 25(3): 148-152. doi: 10.13201/j.issn.1004-2806.2012.02.007
SUN Yunyu, CHEN Baoan, DING Jiahua, et al. Interpretation of the myelodysplastic syndrome 2011 NCCN diagnosis and treatment guidelines[J]. J Clin Hematol, 2012, 25(3): 148-152. doi: 10.13201/j.issn.1004-2806.2012.02.007
Citation: SUN Yunyu, CHEN Baoan, DING Jiahua, et al. Interpretation of the myelodysplastic syndrome 2011 NCCN diagnosis and treatment guidelines[J]. J Clin Hematol, 2012, 25(3): 148-152. doi: 10.13201/j.issn.1004-2806.2012.02.007

骨髓增生异常综合征2011 NCCN诊疗指南解读

  • 基金项目:

    江苏省医学重点学科资助

    国家科技支撑计划课题(十一五)子课题(No:2008BAI61B02)

详细信息
    通讯作者: 陈宝安,E-mail:cba8888@hotmail.com
  • 中图分类号: R551.3

Interpretation of the myelodysplastic syndrome 2011 NCCN diagnosis and treatment guidelines

More Information
  • 目的:为国内骨髓增生异常综合征(MDS)规范诊断治疗提供参考。方法:对美国国家综合癌症网络(NCCN)2011年版MDS临床指南进行解读。从MDS的诊断分型、初始评估、预后分层及治疗选择方面进行全面阐述,以期对国内MDS的规范诊疗有所帮助。结果:NCCN MDS诊疗指南是基于对不同风险患者研究数据的广泛评价,代表了目前MDS诊断治疗的有效方法。结论:NCCN 2011版MDS诊疗指南可以为国内同行提供很好的借鉴。
  • 加载中
  • [1]

    VARDIMAN J W,HARRIS N L,BRUNNING R D.The World Health Organization(WHO)classification of the myeloid neoplasmas[J].Blood,2002,100:2292-2302.

    [2]

    GREENBERG P,COX C,LEBEAU M M,et al.International scoring system for evaluating prognosis in myelodysplastic syndromes[J].Blood,1997,89:2079-2088.

    [3]

    VALENT P,HORNY H P,BENNETT J M,et al.Definitions and standars in the diagnosis and treatment of the myelodysplastic syndromes:Consensus statements and report from a working conference[J].Leuk Res,2007,31:727-736.

    [4]

    DUNN D E,TANAWATTANACHAROEN P,BOCCUNI P,et al.Paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure syndromes[J].Ann Intern Med,1999,131:401-408.

    [5]

    SAUNTHARARAJAH Y,NAKAMURA R,NAM J M,et al.HLA-DR15(DR2)is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome[J].Blood,2002,100:1570-1574.

    [6]

    GREGG X T,REDDY V,PRCHAL J T.Copper deficiency masquerading as myelodysplastic syndrome[J].Blood,2002,100:1493-1495.

    [7]

    KOCA E,BUYUKASIK Y,CETINER D,et al.Copper deficiency with increased hematogones mimicking refractory anemia with excess blasts[J].Leuk Res,2008,32:495-499.

    [8]

    SANZ G F,SANE M A,GREENBERG P L.Prognostic factors and scoring systems in myelodysplastic syndromes[J].Haematologica,1998,83:358-368.

    [9]

    CERMAK J,KACIRKOVA P,MIKULENKOVA D,et al.Impact of transfusion dependency on survival in patients with early myelodysplastic syndrome without excess of blasts[J].Leuk Res,2009,33:1469-1474.

    [10]

    PARK M J,KIM H J,KIM S H,et al.Is international Prognostic Scoring System(IPSS)still standard in predicting prognosis in patients with myelodysplastic syndrome? External validation of the WHO Classification-Based Prognostic Scoring System(WPSS)and comparision with IPSS[J].Eur J Haematol,2008,81:364-373.

    [11]

    MALCOVATI L.Impact of transfusion dependency and secondary iron overload on the survival of patients with myelodysplastic syndromes[J].Leuk Res,2007,31 Suppl 3:2-6.

    [12]

    JENSEN P D,HEICKENDORFF L,PEDERSEN B,et al.The effect of iron chelation on haemopoiesis in MDS patients with transfusional iron overload[J].Br J Haematol,1996,94:288-299.

    [13]

    FENAUX P,MUFTI G J,HELLSTROM-LINDBERG E,et al.Efficacy of azacitidine compared with that of conventional care regimens in the treatment of high-risk myelodysplastic syndromes:a randomised,openlabel phase Ⅲ study[J].Lancet Oncol,2009,10:223-232.

    [14]

    KANTARJIAN H,ISSA J P,ROSENFELD C S,et al.Decitabine improves patient outcomes in myelodysplastic syndromes:results of a phase Ⅲ randomized study[J].Cancer,2006,106:1794-1803.

    [15]

    LIST A,KURTIN S,ROE D J,et al.Efficacy of lenalidomide in myelodysplastic syndromes[J].N Engl J Med,2005,352:549-557.

    [16]

    NIMER S D.Clinical management of myelodysplastic syndromes with interstitial deletion of chromosome 5q[J].J Clin Oncol,2006,24:2576-2582.

    [17]

    ESTEY E H,THALL P F,CORTES J E,et al.Comparison of idarubicin+ara-C,fludarabine+ara-C,and topotecan+ ara-C-based regimens in treatment of newly diagnosed acute myeloid leukemia,refractory anemia with excess blasts in transformation,or refractory anemia with excess blasts[J].Blood,2001,98:3575-3583.

    [18]

    SCOTT B L,SANDMAIER B M,STORER B,et al.Myeloablative vs nonmyeloablative allogeneic transplantation for patients with myelodysplastic syndrome or acute myelogenous leukemia with multilineaga dysplasia:a retrospective analysis[J].Leukemia,2006,20:128-135.

    [19]

    ALYEA E P,KIM H T,HO V,et al.Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age[J].Blood,2005,105:1810-1814.

    [20]

    CUTLER C S,LEE S J,GREENBERG P,et al.A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes:delayed transplantation for low-risk myelodysplassia is associated with improved outcome.Blood[J],2004,104:579-585.

    [21]

    BERAN M,SHEN Y,KANTARJIAN H,et al.High-dose chemotherapy in high-risk myelodysplastic syndrome:covariate-adjusted comparison of five regimens[J].Cancer,2001,92:1999-2015.

    [22]

    WIJERMANS P,SUCIU S,BAILA L,et al.Low dose decitabine versus best supportive care in elderly patients with intermediate or high-risk MDS not eligible for intensive chemotherapy:Final results of the randomized phase Ⅲ study(06011)of the EORTC leukemia and German MDS study groups[J].Blood,2008,112:226-226.

    [23]

    SPIRTI M A,LATAGLIATA R,NISCOLA P,et al.Impact of a new dosing regimen of epoetin alfa on quality of life and anemia in patients with low-risk myelodysplastic syndrome[J].Ann Hematol,2005,84:167-176.

    [24]

    HELLSTROM-LINDBERG E,GULBRANDSEN N,LINBERG G,et al.A validated decision model for treating the anemia of myelodysplastic syndromes with erythropoietin+granulocyte colony-stimulating factor:significant effects on qulity of life[J].Br J Haematol,2003,120:1037-1046.

  • 加载中
计量
  • 文章访问数:  207
  • PDF下载数:  149
  • 施引文献:  0
出版历程
收稿日期:  2011-07-19
修回日期:  2012-01-18

目录