巨幼细胞贫血病:中文医学期刊临床报告资料综述及提示

陈志云; 马绍钧

doi:10.13201/j.issn.1004-2806.2012.04.006

巨幼细胞贫血病:中文医学期刊临床报告资料综述及提示

陈志云^1, ,,
马绍钧²

- 1 香港东区拿打素尤德夫人医院内科部;
- 2 香港跑马地养和医院临床病理化验室

详细信息

通讯作者: 陈志云,E-mail:joycecwchan@hotmail.com

中图分类号: R556

收稿日期: 2012-02-07

Review of clinical reports of megaloblastic anaemia in Chinese medical journals

CHEN Zhiyun^1, ,,
MA Shaojun²

- 1. Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong;
- 2. Clinical Pathology, Hong Kong Sanatorium&Hospital

More Information

Corresponding author: CHEN Zhiyun, E-mail: joycecwchan@hotmail.com

Received Date: 07 February 2012

摘要

摘要: 目的:综合近期在中文医学期刊发表的报告,描述中国内地巨幼细胞贫血的临床和病理特征,并对现行的诊断方法作出评价。方法:从中国知网CNKI(www.cnki.net)医学文献数据库,用"巨幼细胞贫血"为关键词搜索2009-2011年的中文医学期刊。结果:总共鉴定由16个省份发表的29篇关于巨幼细胞贫血的医学报告,包括1 945例患者,男、女患者的人数比例为1.13∶1.00,平均年龄59.5岁。7篇(24%)只报道60岁以上老年患者,22篇(76%)包括所有年龄的患者。26篇(90%)集中报道血液系统的表现,3篇(10%)限于报道神经系统的临床表现。平均Hb为 0.588 g/L,平均红细胞体积(MCV)117.2 fl。46%(741/1 601)患者患有全血细胞减少症,90%(1 756/1 945)患者进行骨髓细胞学检查,63%(1 230/1 945)患者进行血清维生素B₁₂及叶酸检测:49%缺乏维生素B₁₂,59%缺乏叶酸。909例资料显示22%因饮食不足而患病,46%是因肠胃不正常。结论:提倡临床在处理巨幼细胞贫血方面,要进一步正确诊断是缺乏何种维生素,及追查引发维生素缺乏的因素。
- 贫血 /
- 中国 /
- 期刊
Abstract: Objective:To describe the clinical and pathological features of megaloblastic anaemia(MA)in China and to evaluate the current diagnostic approach to MA based on recently published clinical reports in Chinese medical journals.Method:Electronic Chinese medical journals were accessed via www.cnki.net and the key word used for search was megaloblastic anaemia.Result:Twenty nine reports of MA from 16 provinces of China published between 2009 and 2011 were identified and reviewed.1 945 patients were included.The male to female ratio was 1.13 to 1 and the mean age was 59.5 years.Seven(24%)reports only studied elderly patients(>60)only while the rest of 22 reports (76%) explored at all ages.26(90%)reports focused on haematological manifestations while 3(3%) reports focused on neurological features.Of patients with evaluable parameters,the mean Hb level was 0.588 g/L,the mean MCV value was 117.2 fl,46%(741/1 601)had pancytopenia at time of diagnosis.90%(1 756/1 945)patients underwent marrow examination.63%(1 230/1 945)patients had serum B₁₂/folate examination,thus 49% patients were found with vitamin B₁₂ deficiency and 59% patients were with folate deficiency.Causes of deficiency were analyzed in 909 patients.It was due to dietary factors in 22% patitents,but gastrointestinal disorders in 46% patiens.Conclusion:Clear delineation of the type of vitamin deficiency,and search for specific malabsorptive disorders like pernicious anaemia are advocated.
- anaemia /
- China /
- journals

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