Levels of regulatory T cells and concentrations of interleukin-6 and tumor necrosis factor-α in peripheral blood of patients with non-Hodgkin's lymphoma
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摘要: 目的:通过观察非霍奇金淋巴瘤(NHL)患者调节性T淋巴细胞(Treg)及白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α在疾病不同阶段的水平,探索这些免疫因素在NHL预后中的作用。方法:将87例NHL患者按临床预后分为无事件存活组64例、复发组14例、难治组9例,另设健康对照20例,动态观察Treg细胞及IL-6、TNF-α在疾病不同阶段的水平。结果:初治时NHL患者外周血Treg细胞比例、IL-6、TNF-α较对照者显著升高(P<0.05);其中难治组和复发组在起病时的Treg及IL-6水平较无事件存活组更高(P<0.05),而TNF-α水平差异无统计学意义。停止治疗时所有NHL患者外周血Treg、IL-6、TNF-α的水平与对照者比较差异无统计学意义;停止治疗后3个月及6个月时Treg、CD4+T淋巴细胞比例有升高趋势,复发组IL-6、TNF-α较无事件存活组升高,但差异无统计学意义。结论:Treg细胞可能在NHL发病及疾病进展中起促进作用,监测IL-6及TNF-α的表达水平对早期判断难治患者和预测复发可能有重要的临床意义。Abstract: Objective: To investigate the levels of regulatory T cells (Treg) and concentrations of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in peripheral blood of patients with non-Hodgkin's lymphoma (NHL) and to explore their roles in the pathogenesis and prognosis.Method: Eighty-seven patients with NHL were divided into three groups:events-free survival group (n=64),relapse group (n=14) and refractory group (n=9),healthy control group (n=20) was set up as well.The levels of Treg cells and concentrations of IL-6 and TNF-α in peripheral blood of patients were analyzed during different periods.Result: The levels of Treg cells and concentrations of IL-6 were significantly higher in NHL patients,especially in relapse and refractory groups (P<0.05),while there was no difference in TNF-α.At the end of chemotherapy,the levels of Treg cells and concentrations of IL-6 and TNF-α had no difference with healthy control group.More Treg cells and higher concentrations of IL-6 and TNF-α were seen in relapse group than those in event-free group at the time of 3 months or 6 months off treatment (P>0.05).Conclusion: Treg cells may play a key role in the pathogenesis and development of NHL.IL-6 and TNF-α may be useful factors for predicting the relapse and refractory of NHL.
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Key words:
- non-Hodgkin's lymphoma /
- Treg cell /
- IL-6 /
- TNF-α
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