Mantle cell lymphoma with central nervous system infiltration as the initial symptom:a case report and review of literatures
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Abstract: A case of 56 years old male mantle cell lymphoma (MCL) patient with central nervous system infiltration as the initial symptom was reported.He had a progressive limbs numbness and weakness firstly and then appeared chest segmental tension.Electromyography showed the neurogenic damage in double arms.Cerebrospinal fluid infiltration was confirmed by a large number of white blood cells (10.0×106/L) and high concentration of protein (1007 mg/L).Flow cytometry analysis of cerebrospinal fluid revealed 6.7 percent of abnormal cells,positive for CD5 and negative for CD10 expression at the same time.PET-CT demonstrated that there had a mild increased intake of FDG in cervical and thoracic spine without obvious destruction in vertebral body.Routine blood test showed that the number of white blood cells was 21.89×109/L with 31 percent of abnormal cells.Furthermore,the laboratory results showed 5 percent of blast lymphocytic cells in bone marrow and 38.3 percent of monoclonal mature small B lymphocytic cells with CD5-positive and CD10-negative expression in peripheral blood.FISH showed IGH/CCND1(+) fusion gene.At last,this patient was diagnosed with MCL.
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Key words:
- central nervous system infiltration /
- mantle cell lymphoma /
- diagnosis
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