中危急淋方案治疗儿童母细胞性浆细胞样树突细胞肿瘤1例及文献复习

丁丽丽; 刘爱国; 胡群; 张柳清; 张艾; 王雅琴; 余文; 王松咪; 陈萍; 聂第敏

doi:10.13201/j.issn.1004-2806.2019.01.012

中危急淋方案治疗儿童母细胞性浆细胞样树突细胞肿瘤1例及文献复习

- 华中科技大学同济医学院附属同济医院儿童血液科(武汉, 430030)

详细信息

通讯作者: 刘爱国,E-mail:drliuaiguo@163.com

中图分类号: R733

收稿日期: 2018-01-06

Intermediate-risk ALL chemotherapy regimen for child with blastic plasmacytoid dendritic cell neoplasm:A case report and literature review

- Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

More Information

Corresponding author: LIU Aiguo, E-mail: drliuaiguo@163.com

Received Date: 06 January 2018

摘要

摘要: 目的:提高对儿童母细胞性浆细胞样树突细胞肿瘤(BPDCN)的临床及病理特征、诊断和治疗的认识。方法:分析我院1例4岁男孩患BPDCN的临床资料,并进行文献复习。结果:儿童BPDCN罕见,该例BPDCN患儿以皮肤和睾丸受累为主,未累及骨髓。予以ALL-CCLG-2008中危方案治疗,维持期增加培门冬酰胺酶治疗,效果显著,随访至今已无病生存5年半。结论:儿童BPDCN的化疗预后明显好于成人。是否需要高危急性淋巴细胞白血病方案化疗或造血干细胞移植,还需进一步临床病例积累。
- 母细胞性浆细胞样树突细胞肿瘤 /
- 儿童 /
- 治疗 /
- 预后
Abstract: Objective:To improve the understanding of the clinical and pathological features,diagnosis and treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN).Method:Clinical data of a 4-year-old boy with BPDCN in our hospital was analyzed and the related literatures were reviewed.Result:Pediatric BPDCN was very rare.Skin and testis were mainly involved in this case.The child was treated with ALL-CCLG-2008 intermediate-risk regimen and had been in complete remission for 5 year and a half.Conclusion:The prognosis of children with BPDCN is significantly better than that of adults.We should gather more clinical data of pediatric BPDCN to determinate whether high-risk acute lymphoblastic leukemia regimen or hematopoietic stem cell transplantation is necessary.
- blastic plasmacytoid dendritic cell neoplasm /
- children /
- diagnosis /
- prognosis

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