移植前高血清铁蛋白对急性髓系白血病及骨髓增生异常综合征预后影响研究新进展

杨园; 安田丽; 赵丽

doi:10.13201/j.issn.1004-2806.2019.05.019

移植前高血清铁蛋白对急性髓系白血病及骨髓增生异常综合征预后影响研究新进展

- 1. 兰州大学第一临床医学院(兰州, 730000);
- 2. 兰州大学第一医院血液科

详细信息

通讯作者: 赵丽,E-mail:zhaoli@lzu.edu.cn

中图分类号: R733.7

收稿日期: 2018-11-15

Advances in pre-transplantation high serum ferritin on the prognosis of acute myeloid leukemia and myelodysplastic syndrome

More Information

Corresponding author: ZHAO Li, E-mail: zhaoli@lzu.edu.cn

Received Date: 15 November 2018

摘要

- 血清铁蛋白 /
- 急性髓系白血病 /
- 骨髓增生异常综合征 /
- 临床阈值 /
- 预后
Abstract: Iron overload,a pathological state,is the body's iron stores up-regulated,which could cause damages occurred in many organs through the production of reactive oxygen species.Iron deposition in various organs,which not only affects the prognosis of patients but also might influence the progression of the underlying diseases.Serum ferritin (SF) has a limited specificity in terms of assessing the extent of the iron overload (defined as SF>1 000 ng/ml),because the SF levels can be influenced by the acute infection,inflammation and malignancies.Many researches have recently proved that the elevated SF prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) have a negative impact on the prognosis of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).However,the clinical cut-off value of pre-tranplantation elevated SF associated with the poor prognosis of AML and MDS patients undergoing allo-HSCT ranging from 500 to 2 500 ng/ml,varied considerably.We comprehensively searched the China National Knowledge Infrastructure,PubMed and Web of Science,with the purpose of systematic reviewing the latest progress of researches focused on investigating the prognostic role of pre-transplantation elevated SF in patients with MDS and AML who underwent allo-HSCT.
- serum ferritin /
- acute myeloid leukemia /
- myelodysplastic syndrome /
- clinical cut-off value /
- prognosis

HTML全文

参考文献(34)

[1]	Wang J, Pantopoulos K.Regulation of cellular iron metabolism[J].Biochem J, 2011, 434:365-381.
[2]	Papanikolaou G, Pantopoulos K.Systemic iron homeostasis and erythropoiesis[J].IUBMB Life, 2017, 69:399-413.
[3]	Yanatori I, Kishi F.DMT1 and iron transport[J].Free Radic Biol Med, 2019, 133:55-63.
[4]	Moukalled NM, El Rassi FA, Temraz SN, et al.Iron overload in patients with myelodysplastic syndromes:An updated overview[J].Cancer, 2018, 124:3979-3989.
[5]	Nemeth E, Tuttle MS, Powelson J, et al.Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization[J].Science, 2004, 306:2090-2093.
[6]	Winter WE, Bazydlo LA, Harris NS.The molecular biology of human iron metabolism[J].Lab Med, 2014, 45:92-102.
[7]	Babitt JL, Huang FW, Wrighting DM, et al.Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression[J].Nat Genet, 2006, 38:531-539.
[8]	Niederkofler V, Salie R, Arber S.Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload[J].J Clin Invest, 2005, 115:2180-2186.
[9]	Silvestri L, Pagani A, Nai A, et al.The serine protease matriptase-2(TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin[J].Cell Metab, 2008, 8:502-511.
[10]	Kautz L, Jung G, Valore EV, et al.Identification of erythroferrone as an erythroid regulator of iron metabolism[J].Nat Genet, 2014, 46:678-684.
[11]	Tanno T, Porayette P, Sripichai O, et al.Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells[J].Blood, 2009, 114:181-186.
[12]	Shah YM, Matsubara T, Ito S, et al.Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency[J].Cell Metab, 2009, 9:152-164.
[13]	Rishi G, Wallace DF, Subramaniam VN.Hepcidin:regulation of the master iron regulator[J].Biosci Rep, 2015, 35:e00192.
[14]	Delaby C, Pilard N, Puy H, et al.Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages:early mRNA induction by haem, followed by iron-dependent protein expression[J].Biochem J, 2008, 411:123-131.
[15]	Italia K, Colah R, Ghosh K.Experimental animal model to study iron overload and iron chelation and review of other such models[J].Blood Cells Mol Dis, 2015, 55:194-199.
[16]	Porter JB, de Witte T, Cappellini MD, et al.New insights into transfusion-related iron toxicity:Implications for the oncologist[J].Crit Rev Oncol Hematol, 2016, 99:261-271.
[17]	Cabantchik ZI, Breuer W, Zanninelli G, et al.LPI-labile plasma iron in iron overload[J].Best Pract Res Clin Haematol, 2005, 18:277-287.
[18]	Zuo Y, Xiang B, Yang J, et al.Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1[J].Cell Res, 2009, 19:449-457.
[19]	Alessandrino EP, Della Porta MG, Bacigalupo A, et al.Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation:a GITMO study[J].Haematologica, 2010, 95:476-484.
[20]	Tachibana T, Tanaka M, Takasaki H, et al.Pretransplant serum ferritin is associated with bloodstream infections within 100 days of allogeneic stem cell transplantation for myeloid malignancies[J].Int J Hematol, 2011, 93:368-374.
[21]	Jacobi N, Herich L.Measurement of liver iron concentration by superconducting quantum interference device biomagnetic liver susceptometry validates serum ferritin as prognostic parameter for allogeneic stem cell transplantation[J].Eur J Haematol, 2016, 97:336-341.
[22]	Anderson LJ.Assessment of iron overload with T2* magnetic resonance imaging[J].Prog Cardiovasc Dis, 2011, 54:287-294.
[23]	Dohner H, Estey E, Grimwade D, et al.Diagnosis and management of AML in adults:2017 ELN recommendations from an international expert panel[J].Blood, 2017, 129:424-447.
[24]	Tachibana T, Tanaka M, Yamazaki E, et al.Multicenter validation of scoring system of pre-transplant serum ferritin and disease risk in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic hematopoietic stem cell transplant[J].Leuk Lymphoma, 2013, 54:1318-1320.
[25]	Finke J, Schmoor C, Bertz H, et al.Long-term follow-up of therapy-related myelodysplasia and AML patients treated with allogeneic hematopoietic cell transplantation[J].Bone Marrow Transplant, 2016, 51:771-777.
[26]	Boehm A, Sperr WR, Kalhs P, et al.Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia:a single center experience[J].Wien Klin Wochenschr, 2014, 126:23-29.
[27]	Atilla E, Toprak SK, Demirer T.Current review of iron overload and related complications in hematopoietic stem cell transplantation[J].Turk J Haematol, 2017, 34:1-9.
[28]	Kim YR, Kim JS, Cheong JW, et al.Transfusion-associated iron overload as an adverse risk factor for transplantation outcome in patients undergoing reduced-intensity stem cell transplantation for myeloid malignancies[J].Acta Haematol, 2008, 120:182-189.
[29]	Komrokji RS, Corrales-Yepez M, Kharfan-Dabaja MA, et al.Hypoalbuminemia is an independent prognostic factor for overall survival in myelodysplastic syndromes[J].Am J Hematol, 2012, 87:1006-1009.
[30]	Jang JE, Kim SJ, Cheong JW, et al.Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia[J].Ann Hematol, 2015, 94:275-282.
[31]	Lim ZY, Fiaccadori V, Gandhi S, et al.Impact of pre-transplant serum ferritin on outcomes of patients with myelodysplastic syndromes or secondary acute myeloid leukaemia receiving reduced intensity conditioning allogeneic haematopoietic stem cell transplantation[J].Leuk Res, 2010, 34:723-727.
[32]	Artz AS, Logan B, Zhu X, et al.The prognostic value of serum C-reactive protein, ferritin, and albumin prior to allogeneic transplantation for acute myeloid leukemia and myelodysplastic syndromes[J].Haematologica, 2016, 101:1426-1433.
[33]	Yan Z, Chen X, Wang H, et al.Effect of pre-transplantation serum ferritin on outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation:A meta-analysis[J].Medicine (Baltimore), 2018, 97:e10310.
[34]	Pileggi C, Di Sanzo M, Mascaro V, et al.Role of serum ferritin level on overall survival in patients with myelodysplastic syndromes:Results of a meta-analysis of observational studies[J].PLoS One, 2017, 12:e0179016.