《组蛋白去乙酰化酶抑制剂chidamide治疗多发性骨髓瘤溶骨性病变的机制研究》解读

陈青骁, 蔡真. 《组蛋白去乙酰化酶抑制剂chidamide治疗多发性骨髓瘤溶骨性病变的机制研究》解读[J]. 临床血液学杂志, 2019, 32(7): 504-507. doi: 10.13201/j.issn.1004-2806.2019.07.004
引用本文: 陈青骁, 蔡真. 《组蛋白去乙酰化酶抑制剂chidamide治疗多发性骨髓瘤溶骨性病变的机制研究》解读[J]. 临床血液学杂志, 2019, 32(7): 504-507. doi: 10.13201/j.issn.1004-2806.2019.07.004
CHEN Qingxiao, CAI Zhen. Comments on “Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease”[J]. J Clin Hematol, 2019, 32(7): 504-507. doi: 10.13201/j.issn.1004-2806.2019.07.004
Citation: CHEN Qingxiao, CAI Zhen. Comments on “Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease”[J]. J Clin Hematol, 2019, 32(7): 504-507. doi: 10.13201/j.issn.1004-2806.2019.07.004

《组蛋白去乙酰化酶抑制剂chidamide治疗多发性骨髓瘤溶骨性病变的机制研究》解读

  • 基金项目:

    国家自然科学基金面上项目(No:81872322)

详细信息
    通讯作者: 蔡真,E-mail:caiz@zju.edu.cn
  • 中图分类号: R733.3

Comments on “Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease”

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  • [1]

    Fairfield H, Falank C, Avery L, et al.Multiple myeloma in the marrow:pathogenesis and treatments[J].Ann N Y Acad Sci, 2016, 1364:32-51.

    [2]

    Palumbo A, Anderson K.Multiple myeloma[J].N Engl J Med, 2011, 364:1046-1060.

    [3]

    Panaroni C, Yee AJ, Raje NS.Myeloma and bone disease[J].Curr Osteoporos Rep, 2017, 15:483-498.

    [4]

    Li Y, Zheng Y, Li T, et al.Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma[J].Oncotarget, 2015, 6:24218-24229.

    [5]

    Roodman GD.Pathogenesis of myeloma bone disease[J].Leukemia, 2009, 23:435-441.

    [6]

    An G, Acharya C, Feng X, et al.Osteoclasts promote immune suppressive microenvironment in multiple myeloma:therapeutic implication[J].Blood, 2016, 128:1590-603.

    [7]

    Reagan MR, Liaw L, Rosen CJ, et al.Dynamic interplay between bone and multiple myeloma:emerging roles of the osteoblast[J].Bone, 2015, 75:161-169.

    [8]

    Seto E, Yoshida M.Erasers of histone acetylation:the histone deacetylase enzymes[J].Cold Spring Harb Perspect Biol, 2014, 6:a018713.

    [9]

    Harada T, Ohguchi H, Grondin Y, et al.HDAC3 regulates DNMT1 expression in multiple myeloma:therapeutic implications[J].Leukemia, 2017, 31:2670-2677.

    [10]

    Dou C, Li N, Ding N, et al.HDAC2 regulates FoxO1 during RANKL-induced osteoclastogenesis[J].Am J Physiol Cell Physiol, 2016, 310:C780-C787.

    [11]

    Cantley MD, Fairlie DP, Bartold PM, et al.Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro[J].J Cell Physiol, 2011, 226:3233-3241.

    [12]

    Santo L, Hideshima T, Kung AL, et al.Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma[J].Blood, 2012, 119:2579-2589.

    [13]

    Mishima Y, Santo L, Eda H, et al.Ricolinostat (ACY-1215) induced inhibition of aggresome formation accelerates carfilzomib-induced multiple myeloma cell death[J].Br J Haematol, 2015, 169:423-434.

    [14]

    San-Miguel JF, Einsele H, Moreau P.The role of panobinostat plus bortezomib and dexamethasone in treating relapsed or relapsed and refractory multiple myeloma:a European perspective[J].Adv Ther, 2016, 33:1896-1920.

    [15]

    Shi Y, Jia B, Xu W, et al.Chidamide in relapsed or refractory peripheral T cell lymphoma:a multicenter real-world study in China[J].J Hematol Oncol, 2017, 10:69.

    [16]

    Gong K, Xie J, Yi H, et al.CS055(Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells[J].Biochem J, 2012, 443:735-746.

    [17]

    Terpos E, Ntanasis-Stathopoulos I, Gavriatopoulou M, et al.Pathogenesis of bone disease in multiple myeloma:from bench to bedside[J].Blood Cancer J, 2018, 8:7.

    [18]

    Bringhen S, De Wit E, Dimopoulos MA.New agents in multiple myeloma:an examination of safety profiles[J].Clin Lymphoma Myeloma Leuk, 2017, 17:391-407.

    [19]

    Pavithra L, Mukherjee S, Sreenath K, et al.SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription[J].J Mol Biol, 2009, 388:691-702.

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出版历程
收稿日期:  2019-05-18

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