费城染色体阴性急性髓系白血病复发后出现费城染色体1例报道并文献复习

朱松涛; 于萍; 陈琳; 米瑞华; 魏旭东

doi:10.13201/j.issn.1004-2806.2020.01.016

费城染色体阴性急性髓系白血病复发后出现费城染色体1例报道并文献复习

- 郑州大学附属肿瘤医院/河南省肿瘤医院血液科(郑州, 450008)
基金项目:
二○一七年度河南省医学科技攻关计划项目(No:201701027)

详细信息

通讯作者: 魏旭东,E-mail:weixudong63@126.com

中图分类号: R733.71

收稿日期: 2019-05-27

Acute myeloid leukemia with a late-appearing Philadelphia chromosome:a case report and literature review

More Information

Corresponding author: WEI Xudong, E-mail: weixudong63@126.com

Received Date: 27 May 2019

摘要

摘要: 费城染色体由9号和22号染色体易位形成特征性Ph染色体和具有酪氨酸激酶活性的BCR-ABL融合蛋白,是慢性粒细胞白血病的重要细胞遗传学标志。此外,Ph染色体也常见于高危急性淋巴细胞白血病。急性髓系白血病（acute myeloid leukemia,AML）患者出现Ph染色体临床上十分罕见,检出率仅约0.5%～3.0%[1-3]。Ph阳性AML发生率较低,缓解率低,预后差。Ph阴性AML复发为Ph阳性AML极为罕见,国内尚未发现相关报道
- 急性髓系白血病 /
- 费城染色体 /
- BCR-ABL融合基因 /
- 复发
Abstract: To improve the understanding and experience of the rare disease of Philadelphia chromosome appearing during recurrence of Ph-negative acute myeloid leukemia(AML),a case of 66-year-old male AML-M5 patient achieved complete remission after induction by DA regimen,but relapsed after 5 cycles of consolidation chemotherapy was studied.Chromosomal analysis showed the appearance of a Philadelphia chromosome and FISH studies revealed the BCR-ABL rearrangement.Imatinib was given orally,combined with lenalidomide,human recombinant interferon alpha-1 b and interleukin-2.The patient died of pulmonary infection.Late-appearing Philadelphia chromosome was associated with poor prognosis,playing a role in clonal evolution and disease progression.Tyrosine kinase inhibitors could benefit patients as a salvage treatment for AML with a late-appearing Philadelphia chromosome.
- acute myeloid leukemia /
- Philadelphia chromosome /
- BCR-ABL fusion gene /
- relapse

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参考文献(17)

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