呈现急性早幼粒细胞白血病表现的特殊亚型白血病

金春香; 韩晓雁; 蔡真

doi:10.13201/j.issn.1004-2806.2020.11.018

呈现急性早幼粒细胞白血病表现的特殊亚型白血病

- 浙江大学附属第一医院骨髓移植中心(杭州, 310003)

详细信息

通讯作者: 蔡真,E-mail:caiz@zju.edu.cn

中图分类号: R733.71

收稿日期: 2020-05-20

Special subtypes of leukemia presenting with acute promyelocytic leukemia

More Information

Corresponding author: CAI Zhen, E-mail: caiz@zju.edu.cn

Received Date: 20 May 2020

摘要

- 变异型急性早幼粒细胞白血病 /
- RARB重排 /
- RARG重排 /
- 维甲酸耐药
Abstract: Some subtypes of acute myeloid leukemia（AML）share morphologic,immunophenotypic and clinical features of acute promyelocytic leukemia（APL）,but absent PML-RARA fusion genes.In some cases,RARA was fuse with other partner genes,the sensitivity of these APL variants to all-trans retinoic acid（ATRA）was different.Furthermore,a few of AML patients resembling typical APL had the retinoic acid receptor beta（RARB）or retinoic acid receptor gamma（RARG）rearranged,and most of these subtypes of AML exhibited resistance to ATRA,with undoubtedly poor the prognosis.In this review,we will discuss these special subtypes of leukemia,in order to early diagnose and improve the prognosis of these patients.
- acute promyelocytic leukemia variants /
- RARB rearrangement /
- RARG rearrangement /
- resistance to ATRA

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