常规检验项目在多发性骨髓瘤诊断中的临床价值

刘志伟; 李晓婷; 逄婷; 郭桂凤

doi:10.13201/j.issn.1004-2806.2021.01.011

常规检验项目在多发性骨髓瘤诊断中的临床价值

- 广州市番禺区中心医院检验科(广州, 511400)
基金项目:
广州市番禺区科技局基金项目(No:2018-Z04-65)

详细信息

通讯作者: 刘志伟,E-mail:seagul-goahead@163.com

中图分类号: R733.3

收稿日期: 2020-09-20

The clinical value of routine tests in the diagnosis of multiple myeloma

- Department of Clinical Laboratory, Panyu Central Hospital, Guangzhou, 511400, China

More Information

Corresponding author: LIU Zhiwei, E-mail: seagul-goahead@163.com

Received Date: 20 September 2020

摘要

摘要: 目的:探索常规检验项目在多发性骨髓瘤(MM)诊断中的临床价值。方法:收集2012年1月—2019年9月在我院确诊的MM患者75例(病例组)和健康体检人群75例(对照组)。对病例组与对照组在常规检验项目中的白细胞计数(WBC)、中性粒细胞比例(NEUT%)、淋巴细胞比例(Lym%)、单核细胞比例(Mon%)、血红蛋白(Hb)、血小板计数(PLT)、血清总蛋白(TP)、血清球蛋白(Glb)、血清尿素(Urea)和血清肌酐(Crea)的数据进行均值及阳性率(结果不在参考范围内定义为阳性)比较,并对相应项目的阳性率进行病例组内比较,进一步筛选明显有异常的项目进行Logistic回归分析及受试者工作特征曲线分析,从而探索常规检验项目在MM诊断中的临床价值。结果:病例组和对照组比较,WBC、NEUT%、Lym%在均值水平上差异无统计学意义,其余项目均差异有统计学意义(P＜0.01);2组阳性率比较均差异有统计学意义(P＜0.01)。病例组内进行比较发现,Hb(96.0%)、Glb(85.3%)和TP(77.3%)的阳性率显著高于其他项目(P＜0.01),其余项目的阳性率均低于70.0%;联合Hb和Glb做Logistic回归分析并做受试者工作特征曲线分析,提示这两者联合对MM的预测及诊断价值较大。结论:常规检查项目的有效应用可为MM的诊断提供重要线索,可以减少MM的误漏诊,具有重要的临床价值。
- 多发性骨髓瘤 /
- 常规检验项目 /
- 临床应用
Abstract: Objective: To explore the clinical values of the routine test items in diagnosis of multiple myeloma(MM).Methods: We collected 75 patients(case group) and 75 healthy people(control group) from our hospital that were diagnosed with MM from January 2012 to September 2019. The mean value and positive rate(the result was not defined as positive within the reference range) of the data of white blood cell count(WBC), neutrophil ratio(NEUT%), lymphocyte ratio(Lym%), monocyte ratio(Mon%), hemoglobin(Hb), platelet count(PLT), total protein(TP), globulin(Glb), urea(Urea) and creatinine(Crea) in case group and control group were analyzed and compared, and the positive rate of the corresponding items was compared within the case group, further screening the obvious abnormal items for Logistic regression analysis and ROC curve analysis, so as to explore the clinical value of routine test items in the diagnosis of MM.Results: Compared between the two groups, WBC, NEUT%, Lym% were not statistically different in the mean level, but there were significant differences in the rest(P＜0.01). All the positive rate was statistically significant difference between the two groups(P＜0.01). Within the case group, the positive rates of Hb(96.0%), Glb(85.3%) and TP(77.3%) had significant differences(P＜0.01) comparing with other items whose positive rates were lower than 70.0%. Combined with Hb, Glb for Logistic regression analysis and ROC curve analysis, it suggested that the combination of them had great value in the prediction and diagnosis of MM.Conclusion: The effective application of routine test items has great clinical value in the diagnosis of MM, and is of great significance in reducing the misdiagnosis and missed diagnosis of MM.
- multiple myeloma /
- routine inspection item /
- clinical application

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