Study on the relationship between peripheral blood neutrophil/lymphocyte ratio and thrombotic events in polycythemia eukaryotes
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摘要: 目的:探讨外周血中性粒细胞/淋巴细胞比值(NLR)对真性红细胞增多症(PV)患者初诊时血栓事件及未来血栓事件进展的相关性研究。方法:收集2013年1月—2020年8月本院PV患者的临床及随访资料,分析PV患者血栓事件的危险因素。结果:Logistic多因素分析发现,高血压、白细胞计数>10×109/L是初诊PV患者血栓事件独立预测因素;未来血栓事件进展的预测与年龄(P<0.05),NLR(P<0.05),初诊时血栓病史(P<0.05),脾肿大(P<0.05)相关;ROC曲线表明,NLR与年龄、初诊时血栓史及脾肿大等临床参数相比更能预测未来血栓事件;Kaplan-Meier生存分析结果表明,高NLR组(NLR≥9.218)96个月血栓无进展总生存率为24.7%,而低NLR组(NLR<9.218)血栓无进展总生存率为92.0%。结论:PV患者外周血NLR水平对未来血栓事件进展具有预测价值,但与初诊时已形成的血栓事件无明显相关性。NLR可作为未来血栓事件进展预测指标之一,具有重要临床意义。
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关键词:
- 中性粒细胞与淋巴细胞比值 /
- 真性红细胞增多症 /
- 血栓
Abstract: Objective: To explore the correlation between peripheral blood neutrophil to lymphocyte ratio(NLR) and thrombotic events in patients with polycythemia vera(PV).Methods: We collected the clinical and follow-up data of PV patients in our hospital from January 2013 to August 2020, and analyze the risk factors of thrombotic events in patients with PV.Results: Logistic multivariate analysis showed that hypertension and white blood cell count>10×109/L were independent predictors of thrombotic events in newly diagnosed PV patients; the progression of future thrombotic events was correlated with age(P<0.05), NLR(P<0.05), history of thrombosis at initial diagnosis(P<0.05), splenomegaly(P<0.05). ROC curve showed that NLR was more predictive of future thrombotic events than age, history of thrombosis and splenomegaly. The results of Kaplan-Meier survival analysis showed that high NLR group(NLR≥9.218) had 24.7% thrombosis progression free survival rate, while the low NLR group(NLR<9.218) had 92.0% overall survival rate.Conclusion: The level of NLR in peripheral blood of patients with PV at initial diagnosis has predictive value for the development of future thrombotic events, but there is no significant correlation between NLR level and thrombotic events. NLR can be used as one of the indicators to predict the progress of thrombotic events in the future, which has important clinical significance.-
Key words:
- neutrophil to lymphocyte ratio /
- polycythemia vera /
- thrombosis
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