Comparison of clinical value of infectious markers in ulcerative colitis
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摘要: 目的:比较炎症标志物C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、降钙素原(PCT)对溃疡性结肠炎(UC)临床应用价值。方法:回顾性分析UC患者74例(UC组)和健康体检人群32例(对照组),收集UC患者CRP、SAA、PCT、肠道内镜检测结果、Mayo评分,通过ROC曲线分析CRP、SAA、PCT对UC价值并确定最佳截断值,根据截断值将炎症指标分层,通过单因素分析、二元Logistic回归分析确定炎症指标是否为UC影响因素,相关性分析评价炎症指标与Baron内镜分级、Mayo评分的关系,并对比不同疾病严重程度UC患者炎症指标的差异。结果:CRP、SAA、PCT对UC的ROC曲线下面积(AUC)分别为0.711、0.813、0.636,最佳截断值分别为12.58 mg/L、16.21 mg/L、0.71 ng/mL,AUCSAA>AUCCRP、AUCPCT,(均P<0.05),CRP、PCT均UC的影响因素(均P<0.05),PCT不是UC的影响因素(P>0.05),CRP、SAA、PCT与Baron内镜分级相关系数(r)分别为0.458、0.513、0.329,均P<0.05,rSAA>rCRP>rPCT,SAA、CRP阳性率在Baron内镜分级的上升趋势有统计学意义(均P<0.05),CRP、SAA、PCT与UC患者Mayo评分r值分别为0.384、0.417、0.251,均P<0.05,rSAA>rCRP>rPCT,UC缓解期CRP、PCT、SAA低于活动期,轻度活动期、中度活动期、重度活动期CRP、SAA差异均有统计学意义(均P<0.05)。结论:CRP、SAA、PCT对UC有一定临床价值,SAA反映UC肠道黏膜愈合、疾病严重程度和活动性价值均优于CRP、PCT。Abstract: Objective: To compare the value of C-reactive protein(CRP), serum amyloid A(SAA) and procalcitonin(PCT) in ulcerative colitis(UC).Methods: A retrospective analysis of 74 UC patients who came to our hospital for diagnosis and treatment and 32 healthy physical examination people was conducted, CRP, SAA, PCT, Intestinal endoscopy test results, Mayo score of UC patients were collected, ROC curve was used to analyze the value of CRP, SAA and PCT in UC and determine the best cut-off value. The inflammatory indicators were stratified according to the cutoff value. Whether the inflammatory indicator is an influencing factor of UC was determined by univariate analysis and binary logistic regression analysis. The relationship between inflammatory indicators, Baron endoscopic grading and Mayo score was evaluated by correlation analysis, and the differences in inflammatory indicators of UC patients with different disease severity were compared.Results: The AUC areas of CRP, SAA, and PCT for the diagnosis of UC were 0.711, 0.813 and 0.636, respectively, and the best cut-off values were 12.58 mg/L, 16.21 mg/L and 0.71 ng/mL, AUCSAA>AUCCRP, AUCPCT(both P<0.05), CRP and SAA were both influencing factors of UC(both P<0.05), and PCT was not an influencing factor of UC(P>0.05). The correlation coefficients(r) of CRP, SAA and PCT to Baron endoscopic grading were 0.458, 0.513 and 0.329 respectively, all P<0.05, rSAA>rCRP>rPCT, the upward trend of the positive rate of SAA and CRP in the Baron endoscopic grading was statistically significant(all P<0.05). CRP, SAA and PCT to the Mayo score r values of UC patients were 0.384, 0.417 and 0.251 respectively, all P<0.05, rSAA>rCRP>rPCT. CRP, PCT, SAA in the remission period of UC were lower than those in the active period, there were statistically significant differences in CRP and SAA in light activity period, mild activity, and heavy activity period(all P<0.05).Conclusion: CRP, SAA and PCT may have certain clinical value for UC, SAA is superior to CRP and PCT in intestinal mucosal healing, disease severity and activity of UC.
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Key words:
- ulcerative colitis /
- C-reactive protein /
- serum amyloid A /
- procalcitonin
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