妊娠早期血红蛋白、25-羟维生素D3与妊娠期糖尿病和分娩方式关系的研究

陈婧; 赵英俊; 陈燕萍; 陈慧

doi:10.13201/j.issn.1004-2806.2021.06.007

妊娠早期血红蛋白、25-羟维生素D3与妊娠期糖尿病和分娩方式关系的研究

- 1. 联勤保障部队第九〇九医院(厦门大学附属东南医院)妇产科(福建漳州, 363000);
- 2. 联勤保障部队第九〇九医院(厦门大学附属东南医院)输血科

详细信息

通讯作者: 陈慧,E-mail:Chenhui175@163.com

中图分类号: R587.1

收稿日期: 2020-11-24

Study on relationship between glycohemoglobin in early pregnancy, 25-hydroxyvitamin D3 and gestational diabetes mellitus, delivery methods

- 1. Department of Obstetrics and Gynecology, No. 909 Hospital of Joint Logistics Support Force[Southeast Hospital Affiliated to Xiamen University], Zhangzhou, 363000, China;
- 2. Department of Blood Transfusion, No. 909 Hospital of Joint Logistics Support Force[Southeast Hospital Affiliated to Xiamen University

More Information

Corresponding author: CHEN Hui, E-mail: Chenhui175@163.com

Received Date: 24 November 2020

摘要

摘要: 目的:探讨妊娠早期血红蛋白(Hb)、25-羟维生素D3[25-(OH)VD3]与妊娠期糖尿病(GDM)、分娩方式的关系。方法:收集2019年6月—2020年4月规律产检孕妇1368例,其中GDM组112例,非GDM组1256例,比较2组间年龄、婴儿性别、Hb、体重指数(BMI)、25-(OH)VD3、血压、孕产史、转氨酶、胰岛细胞功能、妊娠指标和分娩方式差异;将P<0.05指标纳入GDM二元Logistic分析,校正混杂因素后,分析Hb、25-(OH)VD3对GDM影响;通过Spearman相关性分析Hb、25-(OH)VD3与GDM、剖宫产的相关性。结果:GDM组、非GDM组间在年龄、BMI、收缩压、舒展压、糖尿病(DM)家族史、25-(OH)VD3、Hb、空腹血糖(GLU)、稳态模型评估的胰岛β细胞功能指数(HOMA-β)、孕期体重增长数、羊水指数、阴道分娩率、剖宫产率方面差异均有统计学意义(均P<0.05);Hb、25-(OH)VD3、收缩压、舒张压、DM家族史、年龄均为GDM影响因素,OR值分别为1.684、0.643、1.226、1.312、2.321、1.347,校正混杂因素后Hb、25-(OH)VD3 OR值分别为1.962、0.533(均P<0.05);Hb与GDM发生、剖宫产呈正相关,r值分别为0.195、0.164,25-(OH)VD3与GDM发生呈负相关,r值分别为-0.214(均P<0.05)。结论:妊娠早期Hb、25-(OH)VD3均为GDM发生影响因素,早期Hb、25-(OH)VD3检测可以对GDM发生和剖宫产进行一定程度的预测。
- 妊娠期糖尿病 /
- 血红蛋白 /
- 25-羟维生素D3 /
- 剖宫产 /
- 不良妊娠结局
Abstract: Objective: To investigate the relationship between hemoglobin(HB), 25 hydroxyvitamin D3[25-(OH) VD3]and gestational diabetes mellitus(GDM), delivery mode.Methods: A total of 1368 pregnant women who underwent regular delivery inspections in our hospital from June 2019 to April 2020 were collected, including 112 cases in the GDM group and 1256 cases in the non-GDM group. The age, infant sex, Hb, body mass index(BMI), 25-(OH) VD3, blood pressure, history of pregnancy and childbirth, transaminase, pancreatic islet cell function, pregnancy indicators and differences in delivery methods between the two groups were compared. The P<0.05 index was included in the GDM binary Logistic analysis. After adjusting for confounding factors, the impact of Hb and 25-(OH) VD3 on GDM was analyzed. The correlation of Hb and 25-(OH) VD3 with GDM and cesarean section was analyzed by Spearman correlation analysis.Results: There were significant differences in age, BMI, systolic blood pressure, diastolic blood pressure, family history of diabetes mellitus(DM), 25-(OH) VD3, Hb, fasting blood glucose(Glu), HOMA-βcell function index(HOMA-β), weight gain during pregnancy, amniotic fluid index, vaginal delivery rate and cesarean section rate between GDM group and non GDM group(all P<0.05). Hb, 25-(OH) VD3, systolic blood pressure, diastolic blood pressure, family history of DM and age were all influencing factors of GDM, and OR values were 1.684, 0.643, 1.226, 1.312, 2.321 and 1.347, respectively. After adjusting for confounding factors, OR values of Hb and 25-(OH) VD3 were 1.962 and 0.533(both P<0.05). Hb was positively correlated with the occurrence of GDM and cesarean section with r values of 0.195 and 0.164, and 25-(OH) VD3 was negatively correlated with the occurrence of GDM and cesarean section with r values of-0.214(P<0.05).Conclusion: Hb and 25-(OH) VD3 in early pregnancy mgiht be all influencing factors of GDM. Early detection of Hb and 25-(OH) VD3 could predict the occurrence of GDM and cesarean section to a certain extent.
- gestational diabetes mellitus /
- hemoglobin /
- 25-hydroxyvitamin D3 /
- cesarean section /
- adverse pregnancy outcomes

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