Application of BCL2inhibitor Venetoclax combined with chemotherapy in three recurrent and refractory acute myeloid leukemia patients and literature review
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关键词:
- 复发难治急性髓系白血病 /
- BCL2抑制剂 /
- Venetoclax
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Key words:
- refractory/recurrent acute myeloid leukemia /
- BCL2 inhibitor /
- Venetoclax
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[1] Sarkozy C,Gardin C,Gachard N,et al.Outcome of older patients with acute myeloid leukemia in first relapse[J].Am J Hematol,2013,88(9):758-764.
[2] Tsujimoto Y,Cossman J,Jaffe E.Involvement of the bcl-2 gene in human follicular lymphoma[J].Science,1985,228(4706):1440-1443.
[3] Mehta SV,Shukla SN,Vora HH.Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia:its correlation with FLT3[J].Neoplasma,2013,60(6):666-675.
[4] Del Poeta G,Venditti A,Del Principe MI,et al.Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia(AML)[J].Blood,2003,101(6):2125-2131.
[5] Pan R,Hogdal LJ,Benito JM,et al.Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia[J].Cancer Discov,2014,4(3):362-375.
[6] Konopleva M,Pollyea DA,Potluri J,et al.Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia[J].Cancer Discov,2016,6(10):1106-1117.
[7] DiNardo CD,Pratz K,Pullarkat V,et al.Venetoclax combined with decitabine or azacitidine in treatment-naive,elderly patients with acute myeloid leukemia[J].Blood,2019,133(1):7-17.
[8] Wei A,Strickland SA,Roboz GJ,et al.Phase 1/2 Study of Venetoclax with Low-Dose Cytarabine in Treatment-Naive,Elderly Patients with Acute Myeloid Leukemia Unfit for Intensive Chemotherapy:1-Year Outcomes[J].Blood,2017,130(Suppl 1):890-890.
[9] Kontro M,Kumar A,Majumder MM,et al.HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia[J].Leukemia,2017,31(2):301-309.
[10] Pollyea DA,Stevens BM,Jones CL,et al.Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia[J].Nat Med,2018,24(12):1859-1866.
[11] Karjalainen R,Pemovska T,Popa M,et al.JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML[J].Blood,2017,130(6):789-802.
[12] Lehmann C,Friess T,Birzele F,et al.Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models[J].J Hematol Oncol,2016,9(1):50.
[13] Han L,Zhang Q,Shi C,et al.Concomitantly Targeting BCL-2 with Venetoclax(ABT-199/GDC0199) and MAPK Signaling with Cobimetinib(GDC-0973) in Acute Myeloid Leukemia Models[J].Blood,2015,126(23):2544-2544.
[14] Fischer MA,Friedlander S,Hogdal L,et al.Combination of Selective Inhibitor of Nuclear Export(SINE)Compounds,Selinexor and KPT-8602,with Venetoclax(ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma[J].Blood,2016,128(22):3949-3949.
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