The mechanism of HLA-loss participating in leukemia relapse after haploidentical transplantation
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关键词:
- HLA-loss /
- 单倍体相合造血干细胞移植 /
- 复发 /
- 急性白血病
Abstract: The loss of HLA molecule expression on tumor cells is one of the characteristics of immune escape. HLA-loss, genomic loss of a mismatched HLA haplotype, contributes to the escape of residual leukemic cells from immune surveillance and killing effect of donor T cells and thus induces leukemia relapse after haploidentical transplantation. HLA-loss has important clinical significance. It not only invalidates donor lymphocyte infusions used for prevention and treatment of post-transplantation relapse, but also increases the risk of graft versus host disease. This review focus on recent research of HLA-loss involved in relapse after haploidentical transplantation, which provides effective exploration on early diagnosis and treatment strategies for post-transplantation leukemia relapse. -
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