Interpretation of “Chinese guidelines for diagnosis,prevention and treatment of thrombophilia(2021)”
-
-
Key words:
- thrombophilia /
- venous thromboembolism /
- diagnosis /
- prevention and treatment
-
表 1 新版指南推荐实验室检查
检测项目 检测内容 血细胞检查 全血细胞分类与计数、网织红细胞计数、外周血涂片 一般检查 尿常规、大便常规、肝功能、肾功能、球蛋白、血脂、乳酸脱氢酶、血型、血糖、同型半胱氨酸等 凝血指标检查 凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、D-二聚体、纤维蛋白/纤维蛋白原降解产物(FDP)、纤维蛋白原(Fg)、内外源性凝血因子水平、血管性血友病因子(VWF)水平、抗凝血酶活性、蛋白C活性、蛋白S游离抗原 免疫指标检查 红细胞沉降率、C反应蛋白、狼疮抗凝物、抗心磷脂抗体、抗β2-糖蛋白Ⅰ(抗β2-GPⅠ)抗体、其他自身免疫抗体以及免疫球蛋白、补体水平 高通量测序 基因诊断 -
[1] 易栓症诊断中国专家共识(2012年版)[J]. 中华血液学杂志, 2012, 33(11): 982-982.
[2] Mammen EF. Pathogenesis of venous thrombosis[J]. Chest, 1992, 102(6 Suppl): 640s-644s.
[3] Crowther MA, Kelton JG. Congenital thrombophilic states associated with venous thrombosis: a qualitative overview and proposed classification system[J]. Ann Intern Med, 2003, 138(2): 128-134. doi: 10.7326/0003-4819-138-2-200301210-00014
[4] Dahlbäck B. Advances in understanding pathogenic mechanisms of thrombophilic disorders[J]. Blood, 2008, 112(1): 19-27. doi: 10.1182/blood-2008-01-077909
[5] Margaglione M, Brancaccio V, Giuliani N, et al. Increased risk for venous thrombosis in carriers of the prothrombin G-->A20210 gene variant[J]. Ann Intern Med, 1998, 129(2): 89-93. doi: 10.7326/0003-4819-129-2-199807150-00003
[6] Mateo J, Oliver A, Borrell M, et al. Laboratory evaluation and clinical characteristics of 2, 132 consecutive unselected patients with venous thromboembolism--results of the Spanish Multicentric Study on Thrombophilia(EMET-Study)[J]. Thromb Haemost, 1997, 77(3): 444-451. doi: 10.1055/s-0038-1655986
[7] Tang L, Hu Y. Ethnic diversity in the genetics of venous thromboembolism[J]. Thromb Haemost, 2015, 114(5): 901-909.
[8] Rosendaal FR. Venous thrombosis: a multicausal disease[J]. Lancet, 1999, 353(9159): 1167-1173. doi: 10.1016/S0140-6736(98)10266-0
[9] Varga EA, Kujovich JL. Management of inherited thrombophilia: guide for genetics professionals[J]. Clin Genet, 2012, 81(1): 7-17. doi: 10.1111/j.1399-0004.2011.01746.x
[10] Downes K, Megy K, Duarte D, et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders[J]. Blood, 2019, 134(23): 2082-2091. doi: 10.1182/blood.2018891192