以神经痛为首发症状的母细胞性浆细胞样树突细胞肿瘤1例

艾月盈, 刘辉, 宁尚勇, 等. 以神经痛为首发症状的母细胞性浆细胞样树突细胞肿瘤1例[J]. 临床血液学杂志, 2022, 35(11): 831-834. doi: 10.13201/j.issn.1004-2806.2022.11.016
引用本文: 艾月盈, 刘辉, 宁尚勇, 等. 以神经痛为首发症状的母细胞性浆细胞样树突细胞肿瘤1例[J]. 临床血液学杂志, 2022, 35(11): 831-834. doi: 10.13201/j.issn.1004-2806.2022.11.016
AI Yueying, LIU Hui, NING Shangyong, et al. One case of blastic plasmacytoid dendritic cell neoplasm with neuropathic pain as the initial symptom and literature review[J]. J Clin Hematol, 2022, 35(11): 831-834. doi: 10.13201/j.issn.1004-2806.2022.11.016
Citation: AI Yueying, LIU Hui, NING Shangyong, et al. One case of blastic plasmacytoid dendritic cell neoplasm with neuropathic pain as the initial symptom and literature review[J]. J Clin Hematol, 2022, 35(11): 831-834. doi: 10.13201/j.issn.1004-2806.2022.11.016

以神经痛为首发症状的母细胞性浆细胞样树突细胞肿瘤1例

  • 基金项目:
    国家自然科学基金青年项目(No:81600132)
详细信息
    通讯作者: 冯茹,E-mail:frbld@sina.com
  • 中图分类号: R733

One case of blastic plasmacytoid dendritic cell neoplasm with neuropathic pain as the initial symptom and literature review

More Information
  • 母细胞性浆细胞样树突细胞肿瘤(BPDCN)是一种罕见的高度侵袭性血液系统恶性肿瘤。典型BPDCN常以皮损为首发症状,同时可累及淋巴结、骨髓、中枢神经系统和其他软组织等。该文报道1例以神经痛为首发症状且整个病程中均未出现皮损的不典型BPDCN患者,并通过文献复习讨论本病的诊断及治疗体会。
  • 加载中
  • 图 1  患者骨髓及外周血形态学检查

    图 2  患者骨髓流式细胞免疫分型,肿瘤细胞(橙色)表达CD56、CD4、CD123、CD38、HLA-DR、CD36var

  • [1]

    Petrella T, Bagot M, Willemze R, et al. Blastic NK-cell lymphomas(agranular CD4+CD56+ hematodermic neoplasms): a review[J]. Am J Clin Pathol, 2005, 123(5): 662-675. doi: 10.1309/GJWNPD8HU5MAJ837

    [2]

    Nguyen CM, Stuart L, Skupsky H, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm in the Pediatric Population: A Case Series and Review of the Literature[J]. Am J Dermatopathol, 2015, 37(12): 924-928.

    [3]

    Zhang X, Sun J, Yang M, et al. New perspectives in genetics and targeted therapy for blastic plasmacytoid dendritic cell neoplasm[J]. Crit Rev Oncol Hematol, 2020, 149: 102928. doi: 10.1016/j.critrevonc.2020.102928

    [4]

    Pileri A, Delfino C, Grandi V, et al. Blastic plasmacytoid dendritic cell neoplasm(BPDCN): the cutaneous sanctuary[J]. G Ital Dermatol Venereol, 2012, 147(6): 603-608.

    [5]

    Xiao W, Chan A, Waarts MR, et al. Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia[J]. Blood, 2021, 137(10): 1377-1391. doi: 10.1182/blood.2020007897

    [6]

    Khoury JD. Blastic Plasmacytoid Dendritic Cell Neoplasm[J]. Curr Hematol Malig Rep, 2018, 13(6): 477-483. doi: 10.1007/s11899-018-0489-z

    [7]

    Cota C, Vale E, Viana I, et al. Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm-morphologic and phenotypic variability in a series of 33 patients[J]. Am J Surg Pathol, 2010, 34(1): 75-87. doi: 10.1097/PAS.0b013e3181c5e26b

    [8]

    Riaz W, Zhang L, Horna P, et al. Blastic plasmacytoid dendritic cell neoplasm: update on molecular biology, diagnosis, and therapy[J]. Cancer Control, 2014, 21(4): 279-289. doi: 10.1177/107327481402100404

    [9]

    Wang S, Wang X, Liu M, et al. Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents[J]. Ann Hematol, 2018, 97(4): 563-572. doi: 10.1007/s00277-018-3259-z

    [10]

    Beird HC, Khan M, Wang F, et al. Features of non-activation dendritic state and immune deficiency in blastic plasmacytoid dendritic cell neoplasm(BPDCN)[J]. Blood Cancer J, 2019, 9(12): 99. doi: 10.1038/s41408-019-0262-0

    [11]

    Leroux D, Mugneret F, Callanan M, et al. CD4(+), CD56(+)DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Français de Cytogénétique Hématologique[J]. Blood, 2002, 99(11): 4154-4159. doi: 10.1182/blood.V99.11.4154

    [12]

    Fagan RJ, Dingwall AK. COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer[J]. Cancer Lett, 2019, 458: 56-65. doi: 10.1016/j.canlet.2019.05.024

    [13]

    Kaur E, Agrawal R, Sengupta S. Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?[J]. Front Genet, 2021, 12: 634789. doi: 10.3389/fgene.2021.634789

    [14]

    Voutsadakis IA. Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies[J]. World J Gastroenterol, 2020, 26(11): 1197-1207. doi: 10.3748/wjg.v26.i11.1197

    [15]

    Laribi K, Baugier de Materre A, Sobh M, et al. Blastic plasmacytoid dendritic cell neoplasms: results of an international survey on 398 adult patients[J]. Blood Adv, 2020, 4(19): 4838-4848. doi: 10.1182/bloodadvances.2020002474

    [16]

    何云地, 张曦, 黄瑞昊. 造血干细胞移植治疗非霍奇金淋巴瘤[J]. 临床血液学杂志, 2020, 33(9): 604-608. https://www.cnki.com.cn/Article/CJFDTOTAL-LCXZ202009004.htm

    [17]

    Pagano L, Valentini CG, Pulsoni A, et al. Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study[J]. Haematologica, 2013, 98(2): 239-246. doi: 10.3324/haematol.2012.072645

    [18]

    李娜, 周阳, 赵晨, 等. 单倍型造血干细胞移植与同胞相合造血干细胞移植治疗慢性粒-单核细胞白血病的疗效比较[J]. 临床血液学杂志, 2022, 35(5): 323-327. http://www.whuhzzs.com/article/doi/10.13201/j.issn.1004-2806.2022.05.005

    [19]

    Frankel AE, Woo JH, Ahn C, et al. Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients[J]. Blood, 2014, 124(3): 385-392. doi: 10.1182/blood-2014-04-566737

    [20]

    Economides MP, Rizzieri D, Pemmaraju N. Updates in Novel Therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm(BPDCN)[J]. Curr Hematol Malig Rep, 2019, 14(6): 515-522. doi: 10.1007/s11899-019-00556-2

    [21]

    Pemmaraju N, Lane AA, Sweet KL, et al. Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm[J]. N Engl J Med, 2019, 380(17): 1628-1637. doi: 10.1056/NEJMoa1815105

    [22]

    Kovtun Y, Jones GE, Adams S, et al. A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells[J]. Blood Adv, 2018, 2(8): 848-858.

    [23]

    Maude SL, Laetsch TW, Buechner J, et al. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia[J]. N Engl J Med, 2018, 378(5): 439-448. doi: 10.1056/NEJMoa1709866

    [24]

    Montero J, Stephansky J, Cai T, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax[J]. Cancer Discov, 2017, 7(2): 156-164. doi: 10.1158/2159-8290.CD-16-0999

    [25]

    Iversen KF, Holdgaard PC, Preiss B, et al. Daratumumab for treatment of blastic plasmacytoid dendritic cell neoplasm. A single-case report[J]. Haematologica, 2019, 104(9): e432-e433. doi: 10.3324/haematol.2018.214635

  • 加载中

(2)

计量
  • 文章访问数:  1094
  • PDF下载数:  281
  • 施引文献:  0
出版历程
收稿日期:  2021-11-03
修回日期:  2022-09-23
刊出日期:  2022-11-01

目录