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摘要: 随着富血小板血浆(platelet-rich plasma，PRP)基础研究的日益深入和临床应用的逐渐广泛，目前PRP已应用于骨科、烧伤整形科、疼痛科及生殖医学科等多种学科。近年来，PRP在促进组织修复方面已逐步得到公认，不仅能促进骨折愈合和软组织损伤修复，还具有减轻伤口疼痛、减少创面并发症发生等特点。除此之外，PRP独特的抑菌作用也成为目前研究的热点之一，然而其抗菌谱及潜在的抑菌机制尚不明确。本文就PRP的体内外抑菌作用及潜在的抑菌机制进行综述，以期为PRP用于临床抗感染治疗提供理论依据。Abstract: With the deepening study and the widening clinical application of platelet-rich plasma(PRP), it has been applied in various disciplines such as orthopedics, burn orthopedics, pain medicine and reproductive medicine. In recent years, PRP has been gradually recognized for its ability to promote tissue repair, not only for fracture healing and soft tissue injury repair, but also for reducing wound pain and trauma complications. In addition, the antibacterial effect of PRP has also become one of the hot spots of current research, however, its antibacterial spectrum and potential antibacterial mechanism are still unclear. In this paper, we reviewed the antibacterial effects of PRP in vitro and in vivo and its potential antibacterial mechanisms, in order to provide a theoretical basis for the use of PRP in clinical anti-infective therapy.
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表 1 PRP在不同研究团队体外研究中的抑菌情况
作者(年份) 抗菌谱 + - Burnouf[6](2013) S.aureus；E.coli；K.pneumoniae；P.aeruginosa E.cloacae；B.cereus；B.subtilis；S.epidermidis Li[7](2013) MSSA；MRSA；Group A streptococcus；Neisseria gonorrhoeae； E.coli；P.aeruginosa Drago[8](2013) E.Faecalis；C.albicans；Streptococcus agalactiae；Streptococcus oralis P.aeruginosa Chen[9](2013) S.aureus E.coli；P.aeruginosa Intravia[11](2014) S.aureus；MRSA；E.Faecalis；P.acnes 吕品[12](2016) P.acnes Maghsoudi[14](2017) S.aureus；E.coli；S.epidermidis；Shigella species；Streptococcus agalactiae K.pneumoniae；P.aeruginosa；Salmonella species Çetinkaya[13](2019) MRSA；K.pneumoniae；carbapenem-resistant Pseudomonas aeruginosa vancomycin-resistant Enterococcus spp Li[10](2019) S.aureus +：该细菌被抑制；-：该细菌未被抑制。 
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| 引用本文: |
刘炎, 何颖雨, 刘磊, 等. 富血小板血浆的抑菌作用及其机制的研究进展[J]. 临床血液学杂志, 2023, 36(6): 452-456. doi: 10.13201/j.issn.1004-2806.2023.06.016
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| Citation: |
LIU Yan, HE Yingyu, LIU Lei, et al. Research progress on antibacterial effect and mechanism of platelet-rich plasma[J]. J Clin Hematol, 2023, 36(6): 452-456. doi: 10.13201/j.issn.1004-2806.2023.06.016
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