Chinese experts consensus on diagnosis, treatment and management of critically ill patients in hematology intensive care unit(2025)
-
摘要: 近年来,恶性血液病患者的生存期明显延长,相关血液恶性肿瘤患者严重并发症的发生率亦相应升高;而且往往病情变化急骤。设立血液专科重症单元(hematology intensive care unit,HCU)对于早期识别、集中监护式管理血液危重症患者,提高血液科诊治水平、改善患者预后、降低医患纠纷风险具有重要临床意义。参考综合重症监护单元(intensive care unit,ICU)和血液科建设指南,结合国内临床HCU运行经验,由国内多家血液临床诊疗中心参与的专家组完成此共识。此共识从HCU建立的必要性和重要性、基本配置标准、收治标准、管理制度、原发病治疗原则以及诊疗策略等方面给出了具体的意见,并建议具备相应条件的血液中心应积极建立HCU,以期进一步降低血液重症的死亡率。Abstract: Recently, survival rates for patients with hematological malignancies (HMs) have been improved, but severe complications are also rising accordingly, and can escalate quickly. Establishing a hematology intensive care unit (HCU) is crucial for early detection and centralized monitoring of critically ill patients with hematological disorders, thus enhancing levels of hematology diagnosis and treatment, improving patients' prognosis, and minimizing medical disputes. Based on the guidelines of ICU and hematology department, combined with clinical operation experience of domestic HCU, this consensus is participated by several leading hematology centers in China.It outlines the necessity, configuration, admission standards, management, therapeutic principles, and strategies of diagnosis and treatment for HCU. An expert agreement on managing critically ill HCU patients was achieved. It is suggested that blood disease treatment centers with eligible critieria should actively establish HCU, aiming to further lowering the mortality rate of critically ill hematology patients.
-
-
[1] Azoulay E, Pène F, Darmon M, et al. Managing critically Ill hematology patients: Time to think differently[J]. Blood Rev, 2015, 29(6): 359-367. doi: 10.1016/j.blre.2015.04.002
[2] Azoulay E, Schellongowski P, Darmon M, et al. The Intensive Care Medicine research agenda on critically ill oncology and hematology patients[J]. Intensive Care Med, 2017, 43(9): 1366-1382. doi: 10.1007/s00134-017-4884-z
[3] Al-Dorzi HM, Al Orainni H, Al Eid F, et al. Characteristics and predictors of mortality of patients with hematologic malignancies requiring invasive mechanical ventilation[J]. Ann Thorac Med, 2017, 12(4): 259-265. doi: 10.4103/atm.ATM_21_17
[4] Ferreyro BL, Scales DC, Wunsch H, et al. Critical illness in patients with hematologic malignancy: a population-based cohort study[J]. Intensive Care Med, 2021, 47(10): 1104-1114. doi: 10.1007/s00134-021-06502-2
[5] GrgićMedić M, Gornik I, Gašparović V. Hematologic malignancies in the medical intensive care unit: Outcomes and prognostic factors[J]. Hematology, 2015, 20(5): 247-253. doi: 10.1179/1607845414Y.0000000206
[6] 周发春. 入住ICU的医院内肺炎治疗方法的更新与进展[J]. 中国感染与化疗杂志, 2021, 21(4): 501-504.
[7] Scheich S, Weber S, Reinheimer C, et al. Bloodstream infections with gram-negative organisms and the impact of multidrug resistance in patients with hematological malignancies[J]. Ann Hematol, 2018, 97(11): 2225-2234. doi: 10.1007/s00277-018-3423-5
[8] Weber S, Magh A, Hogardt M, et al. Profiling of bacterial bloodstream infections in hematological and oncological patients based on a comparative survival analysis [J]. Ann Hematol, 2021, 100(6): 1593-1602. doi: 10.1007/s00277-021-04541-9
[9] Jiang L, Wan Q, Ma H. Management strategy for hematological malignancy patients with acute respiratory failure[J]. Eur J Med Res, 2021, 26(1): 108. doi: 10.1186/s40001-021-00579-7
[10] di Domenico EG, Marchesi F, Cavallo I, et al. The impact of bacterial biofilms on end-organ disease and mortality in patients with hematologic malignancies developing a bloodstream infection[J]. Microbiol Spectr, 2021, 9(1): e0055021. doi: 10.1128/Spectrum.00550-21
[11] Adda M, Coquet I, Darmon M, et al. Predictors of noninvasive ventilation failure in patients with hematologic malignancy and acute respiratory failure[J]. Crit Care Med, 2008, 36(10): 2766-2772. doi: 10.1097/CCM.0b013e31818699f6
[12] 中华医学会重症医学分会. 《中国重症加强治疗病房(ICU)建设与管理指南》(2006)[J]. 中国危重病急救医学, 2006, 18(7): 387-388.
[13] 中华医学会重症医学分会. 《中国重症患者转运指南(2010)》(草案)[J]. 中国危重病急救医学, 2010, 22(6): 328-330.
[14] Comeau O. Intrafacility Transport of Critically Ill Adult Patients[J]. Crit Care Nurse, 2020, 40(2): 70-72. doi: 10.4037/ccn2020474
[15] 焦雪萍, 刘瑞云. 重症监护室探视模式研究进展[J]. 护理研究, 2021, 35(5): 851-855.
[16] Gerritsen RT, Hartog CS, Curtis JR. New developments in the provision of family-centered care in the intensive care unit[J]. Intensive Care Med, 2017, 43(4): 550-553. doi: 10.1007/s00134-017-4684-5
[17] Davidson JE, Aslakson RA, Long AC, et al. Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU[J]. Crit Care Med, 2017, 45(1): 103-128. doi: 10.1097/CCM.0000000000002169
[18] Vincent JL, Moreno R, Takala J, et al. The SOFA(Sepsis-related Organ Failure Assessment)score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine[J]. Intensive Care Med, 1996, 22(7): 707-710. doi: 10.1007/BF01709751
[19] Knaus WA, Draper EA, Wagner DP, et al. APACHE Ⅱ: a severity of disease classification system[J]. Crit Care Med, 1985, 13(10): 818-829. doi: 10.1097/00003246-198510000-00009
[20] Hughes WT, Armstrong D, Bodey GP, et al. 2002 Guidelines for the use of antimicrobial agents in neutropenic patients with cancer[J]. Clin Infect Dis, 2002, 34(6): 730-751. doi: 10.1086/339215
[21] 中华医学会重症医学分会. ICU患者深静脉血栓形成预防指南(2009)[J]. 中华内科杂志, 2009, 48(9): 788-792.
[22] 内科住院患者静脉血栓栓塞症预防的中国专家建议写作组, 中华医学会老年医学分会, 中华医学会呼吸病学分会, 等. 内科住院患者静脉血栓栓塞症预防中国专家建议(2015)[J]. 中华老年医学杂志, 2015, 34(4): 345-352. doi: 10.3760/cma.j.issn.0254-9026.2015.04.002
[23] 中华医学会血液学分会血栓与止血学组. 弥散性血管内凝血诊断中国专家共识(2017年版)[J]. 中华血液学杂志, 2017, 38(5): 361-363.
[24] 李耘, 吕媛, 薛峰, 等. 卫生部全国细菌耐药监测网(Mohnarin)2011-2012年革兰阳性菌耐药监测报告[J]. 中国临床药理学杂志, 2014, 30(3): 251-259.
[25] 中华医学会血液学分会, 中国医师协会血液科医师分会. 中国中性粒细胞缺乏伴发热患者抗菌药物临床应用指南(2020年版)[J]. 中华血液学杂志, 2020, 41(12): 969-978. doi: 10.3760/cma.j.issn.0253-2727.2020.12.001
[26] 程斯, 方云, 曹兰艳. HCU感染控制风险管理模式的研究与应用[J]. 临床急诊杂志, 2017, 18(11): 847-850.
[27] Roberts JA, Abdul-Aziz MH, Lipman J, et al. Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions[J]. Lancet Infect Dis, 2014, 14(6): 498-509. doi: 10.1016/S1473-3099(14)70036-2
[28] 中国医师协会血液科医师分会, 中国侵袭性真菌感染工作组. 血液病/恶性肿瘤患者侵袭性真菌病的诊断标准与治疗原则(第六次修订版)[J]. 中华内科杂志, 2020, 59(10): 754-763. doi: 10.3760/cma.j.cn112138-20200627-00624
[29] Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021[J]. Intensive Care Med, 2021, 47(11): 1181-1247. doi: 10.1007/s00134-021-06506-y
[30] Lemiale V, Resche-Rigon M, Mokart D, et al. High-Flow Nasal Cannula Oxygenation in Immunocompromised Patients With Acute Hypoxemic Respiratory Failure: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study[J]. Crit Care Med, 2017, 45(3): e274-e280. doi: 10.1097/CCM.0000000000002085
[31] Cecconi M, Hofer C, Teboul JL, et al. Fluid challenges in intensive care: the FENICE study: A global inception cohort study[J]. Intensive Care Med, 2015, 41(9): 1529-1537. doi: 10.1007/s00134-015-3850-x
[32] 王小明, 袁周, 陈齐红, 等. 不同晶体液早期复苏对感染性休克患者内环境的影响: 一项前瞻性随机对照研究[J]. 中华危重病急救医学, 2018, 30(9): 824-829. doi: 10.3760/cma.j.issn.2095-4352.2018.09.002
[33] 于斌, 田慧艳, 胡振杰, 等. 乳酸清除率和中心静脉血氧饱和度指导严重感染患者液体复苏效果的比较[J]. 中华危重病急救医学, 2013, 25(10): 578-583. doi: 10.3760/cma.j.issn.2095-4352.2013.10.002
[34] 卢君强, 李春盛, 杨佳勇, 等. 无创血流动力学监护系统在高危外科患者复苏治疗中的应用[J]. 中国危重病急救医学, 2003, 15(12): 730-734.
[35] 庄燕, 戴林峰, 程璐, 等. 床旁超声下腔静脉直径联合肺部超声B线积分指导感染性休克患者液体复苏的临床研究[J]. 中华危重病急救医学, 2020, 32(11): 1356-1360. doi: 10.3760/cma.j.cn121430-20200611-00463
[36] 杨向红, 张丽娜, 胡波, 等. 连续性肾替代治疗规范化治疗流程[J/OL]. 中华重症医学电子杂志, 2019, 5(1): 27-31.
[37] 中华医学会重症医学分会. 中国成人ICU镇痛和镇静治疗指南[J]. 中华危重病急救医学, 2018, 30(6): 497-514. doi: 10.3760/cma.j.issn.2095-4352.2018.06.001
[38] Vincent JL, Shehabi Y, Walsh TS, et al. Comfort and patient-centred care without excessive sedation: the eCASH concept[J]. Intensive Care Med, 2016, 42(6): 962-971. doi: 10.1007/s00134-016-4297-4
[39] 洪玉才, 张茂. 成年危重患者营养评估与支持治疗指南[J]. 中华急诊医学杂志, 2009, 18(8): 802-804. doi: 10.3760/cma.j.issn.1671-0282.2009.08.007
[40] 江利冰, 张松, 高培阳, 等. 欧洲临床营养与代谢学会ICU临床营养指南(ESPEN)[J]. 中华急诊医学杂志, 2018, 27(11): 1195-1197. doi: 10.3760/cma.j.issn.1671-0282.2018.11.003
[41] 焦柳英, 杨亚东. 肠内营养支持与肠外营养支持序贯治疗危重患者的临床研究[J]. 临床合理用药杂志, 2015, 8(3): 174-175.
-
计量
- 文章访问数: 2272
- PDF下载数: 310
- 施引文献: 0