内皮微粒在急性移植物抗宿主病内皮损伤发生中的作用及机制研究进展

安博文; 洪梅

内皮微粒在急性移植物抗宿主病内皮损伤发生中的作用及机制研究进展

安博文,
洪梅^,

- 华中科技大学同济医学院附属协和医院血液科(武汉, 430022)
基金项目:
国家自然科学基金面上项目资助（No：81172826）

详细信息

通讯作者: 洪梅,E-mail:meihongcn@yahoo.com.cn

中图分类号: R457.7

收稿日期: 2012-09-11

Research progress on the role and mechanism of endothelial microparticles in acute graft-versus-host disease

AN Bowen,
HONG Mei^,

More Information

Corresponding author: HONG Mei, E-mail: meihongcn@yahoo.com.cn

Received Date: 11 September 2012

摘要

- 异基因造血干细胞移植 /
- 急性移植物抗宿主病 /
- 内皮微粒 /
- 内皮损伤
Abstract: Many studies have proved that endothelial cell injury plays an important role in the initiation and development of acute graft-versus-host disease (aGVHD) and is an early event of tissue injury caused by aGVHD.Endothelial microparticles (EMPs) are cell-membrane vesicles that shed from peripheral-blood endothelial cells when subjected to stress conditions,such as activation,apoptosis and so on.Several studies have indicated that the rise of EMPs suggests severe endothelial damage in patients with aGVHD.EMPs may paticipate in the immune injury of aGVHD through the apoptosis induced by Fas/FasL.We will review the research progress of aGVHD after allogeneic hematopoietic stem cell transplantation and endothelial cell injury,and discusse EMPs and its possible mechanisms in endothelial cell injury during aGVHD.
- allogeneic hematopoietic stem cell transplantation /
- acute graft-versus-host disease /
- endothelial microparticles /
- endothelial injury

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参考文献(14)

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