Abstract: Objective:To evaluate the efficacy of two different transfusion strategies,restrictive transfusion and open transfusion,in the patients with acute upper gastrointestinal hemorrhage.Method:The clinical data of 185 patients with acute upper gastrointestinal hemorrhage in our hospital were retrospectively analyzed.They were divided into two groups according to different blood transfusion schemes.The observation group received restrictive blood transfusion according to the standard of Hb＜70 g/L(n=96) and the control group received open blood transfusion according to the standard of Hb＜90 g/L(n=89).Analysis of blood routine,coagulation parameters,retransfusion rate and incidence of adverse reactions before and after transfusion.Result:The indexes of Hb and Hct in the observation group were significantly higher than those before transfusion within 24 hours after transfusion.It had statistical differences(P＜0.05).The indexes of Hb and Hct in the control group within 24 hours after transfusion had no statistical difference compared with those before transfusion(P＞0.05).The indexes of PT,APTT,re-transfusion rate and adverse reactions were significantly different between the observation group and the control group before and after transfusion.The difference was statistically significant(P＜0.05).Conclusion:Compared with open transfusion,restrictive transfusion had obvious advantages in transfusion strategy for patients with acute upper gastrointestinal hemorrhage.It could significantly improve the anemia status of patients,reduce the incidence of coagulation dysfunction and re-transfusion rate,reduce the occurrence of adverse reactions and ensure the safety of blood transfusion.