36例骨髓增生异常综合征患者铁过载状况调查

韦树懿; 赖永榕

36例骨髓增生异常综合征患者铁过载状况调查

韦树懿,
赖永榕^,

- 广西医科大学第一附属医院血液内科(南宁, 530021)

详细信息

通讯作者: 赖永榕,E-mail:laiyongrong@263.net

中图分类号: R733.3

收稿日期: 2013-05-23

Survey of the iron overload status in 36 patients with myelodysplastic syndrome

WEI Shuyi,
LAI Yongrong^,

- Department of Hematology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China

More Information

Corresponding author: LAI Yongrong, E-mail: laiyongrong@263.net

Received Date: 23 May 2013

摘要

摘要: 目的：调查36例骨髓增生异常综合征（MDS）患者的铁过载发生率及铁过载严重程度。方法：收集MDS患者36例，采用电化学发光法测定其血清铁蛋白（SF）。结果：36例MDS患者的SF为851.42（360.75~7885.62）ng/ml，其中16例（44.4%）SF>1000 ng/ml。14例有输血史，SF为887.14（360.75~7885.62）ng/ml，其中7例（50.0%）SF>1000 ng/ml；22例无输血史，SF为851.42（459.87~5277.71）ng/ml，其中9例（40.9%）SF>1000 ng/ml。SF<1000 ng/ml者（20例）与 SF>1000 ng/ml者（16例）的输血量分别为4 U和36 U，差异有统计学意义（P=0.024）。SF水平与输血总量呈正相关（P=0.000）。不同年龄段间SF值差异有统计学意义（P=0.022）。结论：本组MDS患者中16例（44.4%）出现铁过载。铁过载的发生与输血有关，但无输血史的患者中也有9例（40.9%）出现铁过载。
- 骨髓增生异常综合征 /
- 铁过载
Abstract: Objective: To investigate the incidence and severity of iron overload in 36 patients with myelodysplastic syndrome (MDS).Method: The serum ferritin (SF) was measured by electrochemiluminescence immunoassay (ECLIA) in 36 patients with MDS.Result: In the 36 patients with MDS,the SF value was 851.42(form 360.75 to 7885.62)ng/ml,16 patients (44.4%) with SF>1000 ng/ml.Fourteen patients had a history of blood transfusion,the SF value was 887.14 (from 360.75 to 7885.62)ng/ml,7 cases (50.0%) with SF>1000 ng/ml.Twenty-two patients without history of blood transfusion,the SF value was 851.42(from 459.87 to 5277.71)ng/ml,9 cases (40.9%) with SF>1000 ng/ml.The amount of blood transfusion in patients with SF<1000 ng/ml and SF>1000 ng/ml were 4 U and 36 U (P=0.024).SF was positively correlated with the total blood transfusion (P=0.000).There were significant differences in the SF values among difference ages (P=0.022).Conclusion: In this study,16 patients (44.4%) are iron overloaded.The occurrence of iron overload is correlated with transfusion,but 9 cases (40.9%) in the patients without history of blood transfusion also occurs iron overload.
- myelodysplastic syndrome /
- iron overload

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参考文献(14)

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