CFA治疗糖皮质激素不敏感或不耐受慢性免疫性血小板减少症的临床观察

李英华; 罗建民

CFA治疗糖皮质激素不敏感或不耐受慢性免疫性血小板减少症的临床观察

李英华,
罗建民^,

- 河北医科大学第二医院血液内科河北省血液病重点实验室河北省血液病研究所(石家庄, 100022)

详细信息

通讯作者: 罗建民,E-mail:luojm315@yahoo.com.cn

中图分类号: R554

收稿日期: 2012-05-16

修回日期: 2012-09-03

Clinical observation of caffeic acid in the treatment of chronic immune thrombocytopenia patients who were glucocorticoid-insensitive or intolerant

LI Yinghua,
LUO Jianmin^,

- Department of Hematology, The Second Hospital of Hebei Medical University, Hebei Province Key Laboratory of Hematology, Hebei Institute of Hematology, Shijiangzhuang, 100022, China

More Information

Corresponding author: LUO Jianmin, E-mail: luojm315@yahoo.com.cn

Received Date: 16 May 2012

Revised Date: 03 September 2012

摘要

摘要: 目的：观察咖啡酸片治疗糖皮质激素不敏感或不耐受慢性免疫性血小板减少症的效果。方法：分析咖啡酸片治疗糖皮质激素不敏感或不耐受慢性免疫性血小板减少症的效果，并进行满意度调查。结果：共观察患者62例，良效12例，占19.4%；进步38例，占61.3%；无效12例，占19.4%。咖啡酸片治疗前患者的血小板数量为（27.94±11.31）×10⁹/L，治疗后血小板数量增高至（37.42±13.74）×10⁹/L（P<0.01）。单因素及多因素logistic分析显示年龄及患者对糖皮质激素的反应状态是疗效的独立预后因素（P<0.01）；咖啡酸治疗前后患者生化指标无变化（P>0.05）；满意度调查结果为48例（77.4%）患者对应用咖啡酸片满意。结论：咖啡酸片治疗效果较好，患者满意度高，值得推广应用。
- 免疫性血小板减少症,慢性 /
- 咖啡酸 /
- 糖皮质激素 /
- 不耐受 /
- 不敏感 /
- 疗效
Abstract: Objective: To investigate the treatment efficacy of caffeic acid (CFA) in glucocorticoid-insensitive or intolerant patients with chronic immune thrombocytopenia (CITP).Method: To retrospectively analyze the treatment efficacy of cafeic acid in outpatients with CITP.Result: To summarize the response to CFA, there were 12 patients (19.4%) achieving good effect, 38 patients(61.3%) having improvement, and 12 patients(19.4%) having no effect.The platelet counts were increased to (37.42±13.74)×10⁹/L from (27.94±11.31)×10⁹/L after caffeic acid treatmen with statistical significance (P<0.01).Age and response to glucocorticoid were independent prognostic factors by univariate and multivariate logistic regression analysis (P<0.01).The biochemical indicators had no changes after administration of CFA.48 cases (77.4%) were satisfied with the therapy.Conclusion: Caffeic acid was effective in patients with CITP and good for clinical use.
- immune thrombocytopenia, chronic /
- caffeic acid /
- glucocorticoid /
- insensitive /
- intolerant /
- treatment effectiveness

HTML全文

参考文献(5)

[1]	RODEGHIERO F, STASI R, GERNSHEIMER T, et al.Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults andchildren:report from an international working group[J].Blood, 2009, 114:2003-2004.
[2]	PALAU J, JARQUE I, SANZ M A.Long-term management of chronic immune thrombocytopenic purpura in adults[J].Int J Gen Med, 2010, 21:305-311.
[3]	STASI R.Pathophysiology and therapeutic options in primary immune thrombocytopenia[J].Blood Transfus, 2011, 9:262-273.
[4]	张之南, 沈悌.血液病诊断及疗效标准[M].3版.北京:科学出版社, 2007:172-175.
[5]	林文远, 陈蓓莉, 莫东华.咖啡酸片在特发性血小板减少性紫癜治疗中的疗效观察[J].实用医学杂志, 2009, 25(20):3491-3492.