Clinical research on cross-matched test in patients with platelet transfusion refractoriness
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摘要: 目的:研究血小板输注无效(PTR)患者的发生率,分析运用配合性输血后的临床效果。方法:采用简易致敏红细胞血小板血清学技术(SEPSA)对265例输血多次且输注血小板3次以上的患者进行调查分析,并检测血小板相关抗体,比较血小板配合性输注与随机输注的效果。结果:265例多次输注血小板患者发生PTR 25例(9.43%),其中血小板抗体阳性19例(76%),成功配型12例(63.2%),配型输注患者的CCI值明显高于随机输注的患者。结论:多次输血的患者血小板抗体可直接导致PTR,配合性输注可提高血小板输注效果,提高临床疗效。Abstract: Objective:To study the accidence of the platelet transfusion refractoriness(PTR),and analyze the clinical effect of cross-matched test in the PTR.Method:The platelet associated antibody of 265 patients were examined by SEPSA ways,who repeatedly transfused blood more times and transfused platelet more than three times,and the effect of platelet transfusion after cross-matched transfusion were observed.Result:There were 25 PTR in 265 patients(9.43%),19 of 25 PTR(76%)were found positive of platelet antibody,and in the 19 patients,12 ones(63.2%)were successfully cross-matched.Conclusion:Platelet antibody might lead to PTR. Cross-matched transfusion could enhance the effect of platelet transfusion and improve the clinical efficacy.
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