尿结缔组织生长因子在糖尿病肾病早期肾损伤中的诊断价值

黄银娥

尿结缔组织生长因子在糖尿病肾病早期肾损伤中的诊断价值

黄银娥^,

- 天门市第一人民医院检验科(湖北天门, 431700)

详细信息

通讯作者: 黄银娥,E-mail:tmyyhlr@163.com

中图分类号: R587.1

收稿日期: 2012-12-04

Diagnostic value of urine connective tissue growth factor in diagnosis of early renal injury of diabetic nephropathy

HUANG Yin'e^,

- Department of Clinical Laboratory, Tianmen People Hospital, Tianmen, 431700, China

More Information

Corresponding author: HUANG Yin'e, E-mail: tmyyhlr@163.com

Received Date: 04 December 2012

摘要

摘要: 目的：分析糖尿病肾病患者尿结缔组织生长因子（CTGF）水平，探讨其在糖尿病肾病早期肾损伤中诊断的应用价值。方法：选取我院41例2型糖尿病肾病早期患者作为研究对象，同时选取年龄和性别比例匹配的40例健康体检者作为对照组；采用双抗体夹心酶联免疫吸附法测定尿CTGF水平，采用ROC曲线分析法对尿CTGF诊断糖尿病肾病早期肾损伤的应用价值进行评价。结果：与对照组相比较，糖尿病肾病早期患者CTGF明显升高（P<0.05）；Pearson分析显示：尿CTGF水平与微量白蛋白呈显著正相关（r=0.77，P<0.01）；与血肌酐呈负相关（r=-0.44，P<0.01）；ROC曲线显示：采用尿CTGF水平诊断糖尿病肾病早期肾损伤时的AUC面积为0.80，灵敏度为78.4%，特异性为80.5%。结论：尿CTGF水平的升高与糖尿病肾病早期肾损伤的发生密切相关，尿CTGF在糖尿病肾病早期肾损伤的诊断中有较好的临床应用价值。
- 结缔组织生长因子 /
- 糖尿病肾病 /
- ROC曲线 /
- 诊断价值
Abstract: Objective: To evaluate the clinical value of connective tissue growth factor (CTGF) in the diagnosis of early renal injury in diabetic nephropathy.Method: A total of 41 patients with type II diabetes were enrolled in our study. Another 40 age and sex matched healthy individuals were selected as controls. The urine CTGF levels were measured by double antibody sandwich enzyme-linked immunosorbent assay. The MedCalc software was used to draw the ROC curve to evaluate the value of urine CTGF in diagnosis of diabetic nephropathy renal injury.Result: Compared with healthy individuals,CTGF level in patients with early diabetic nephropathy significantly increased (P<0.05). Pearson's analysis showed that urinary CTGF levels significantly correlated with the UAER (r=0.77,P<0.01);and with Scr (r=-0.44,P<0.01). The ROC curve showed that urine CTGF was a useful marker in diagnosis of early renal injury in diabetic nephropathy with AUC area of 0.80,sensitivity of 78.4% and specificity of 80.5%.Conclusion: Urine CTGF levels are closely related to the occurrence of early renal damage of diabetic nephropathy. Urine CTGF detection might be beneficial for the diagnosis of early renal injury in diabetic nephropathy patients.
- connective tissue growth factor /
- diabetic nephropathy /
- ROC curve /
- diagnostic value

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参考文献(9)

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