IgG抗A（B）效价和新生儿溶血3项对ABO新生儿溶血病的预测及诊断

陶夏叶; 邹丽敏

doi:10.13201/j.issn.1004-2806-b.2018.08.011

IgG抗A（B）效价和新生儿溶血3项对ABO新生儿溶血病的预测及诊断

陶夏叶^,,
邹丽敏

- 江苏省丹阳市人民医院(江苏丹阳, 212300)

详细信息

通讯作者: 陶夏叶,E-mail:593238521@qq.com

中图分类号: R556.6

收稿日期: 2018-03-15

Value of maternal IgG anti-A（B）titres and neonatal hemolysis three trials in predicting and diagnosing ABO hemolytic disease of newborn

TAO Xiaye^,,
ZOU Limin

- Center of Laboratory Medicine, Danyang People's Hospital of Jiangsu Province, Danyang, 212300, China

More Information

Corresponding author: TAO Xiaye, E-mail: 593238521@qq.com

Received Date: 15 March 2018

摘要

摘要: 目的:探讨O型孕妇IgG抗A(B)效价和新生儿溶血3项对ABO新生儿溶血病(HDN)的预测及诊断价值。方法:选取2015-01-2016-12就诊于丹阳市人民医院妇产科的260例母婴血型不合的O型孕妇,产婴后185例为非HDN组,75例诊断为HDN,作为HDN组。运用2-巯基乙醇检测孕妇末次IgG抗A(B)效价,运用微柱凝胶免疫法检测新生儿溶血3项(直接抗人球蛋白试验、游离试验和放散试验)。结果:与正常对照组相比,HDN组的IgG抗A(B)效价、直接抗人球蛋白试验、游离试验和放散试验及新生儿血型均差异有统计学意义(P<0.05)。对有差异的因素进行logistic回归分析,发现游离试验、放散试验对HDN的发生具有统计学意义(P<0.05)。通过ROC曲线分析,求出曲线下面积AUC,通过约登指数计算敏感性与特异性。虽然IgG抗A(B)效价对HDN的发生不具有预测价值(P=0.312),但通过趋势χ²检验发现,随着IgG抗A(B)效价的升高,HDN的发生率也显著增加(χ²=31.63,P<0.05)。结论:游离试验和放散试验对HDN具有诊断价值,IgG抗A(B)效价对HDN不具有预测价值,但IgG抗A(B)效价升高会导致HDN的发生概率增加。
- 新生儿溶血病 /
- IgG抗A(B)效价 /
- 新生儿溶血3项
Abstract: Objective:To investigate the value of maternal IgG anti-A(B)titres and neonatal hemolysis three trials in predicting and diagnosing ABO hemolytic disease of newborn(HDN).Method:A retrospective analysis of 260 cases of maternal IgG anti-A(B)titres and neonatal hemolysis three trials in predicting and diagnosing ABO HDN.Result:IgG anti-A(B)titres,neonatal hemolysis three trials(direct antiglobulin test,free antibodies tese and elution test)and blood type were statistically different between control group and HDN group(P<0.05).Logistic regression analysis was carried out on these factors,free antibodies test and elution test had positive diagnostic value for HDN(P<0.05).Sensitivity and specificity were calculated through ROC curves.Although IgG anti-A(B)titres didn't have predictive value for the development of HDN(P=0.312),but we found that as IgG anti-A(B)titres increased,the incidence of HDN also increased significantly(χ²=31.63,P<0.05).Conclusion:Free antibodies test and elution test had positive diagnostic value for HDN.Although IgG anti-A(B)titres didn't have predictive value for the development of HDN,as IgG anti-A(B)titres increased,the incidence of HDN also increased significantly.
- hemolytic disease of newborn /
- IgG anti-A（B）titres /
- neonatal hemolysis three trials