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摘要: 目的：研究非霍奇金淋巴瘤（NHL）初诊和化疗过程中血清脂联素、瘦素和抵抗素水平的变化。方法：选择45例接受相同的化疗方案的NHL患者，选择50例健康成年人作为对照组。用双抗体夹心ABC-ELISA法测定治疗过程中血清中的脂联素、瘦素和抵抗素水平的变化，同时测定血清中的乳酸脱氢酶浓度。结果：初诊时患者血清中的脂联素水平明显降低（P<0.01），而瘦素和抵抗素的表达明显增高（P<0.01）。经过化疗后，NHL患者血清中的脂联素水平呈现明显上升的趋势（P<0.01），而瘦素和抵抗素水平出现明显下降的趋势（P<0.05）。相关性分析显示治疗过程中的乳酸脱氢酶与脂联素水平呈现明显的负相关（r=-0.635，P=0.003），而与瘦素和抵抗素呈现明显的正相关（分别为r=0.532，P=0.025和r=0.637，P=0.012）。结论：NHL初诊时血清中的脂联素水平明显降低，瘦素和抵抗素水平明显增高，这3种脂肪素的水平随着NHL治疗的进展逐渐趋于正常。Abstract: Objective: To investigate adiponectin, leptin, and resistin levels in patients with non-Hodgkin lymphoma (NHL)at diagnosis and during chemotherapy.Method: ABC-ELLSA was used to detect the adiponectin, leptin, and resistin levels in 45 NHL patients and 50 normal controls.The corresponding lactate dehydrogenase (LDH) levels were also recorded.Result: At diagnosis, mean adiponectin levels were lower compared with controls (P<0.01), and the levels of leptin and resistin were higher(P<0.01).During the chemotherapy, adiponectin increased significantly (P<0.01), while leptin and resistin decreased (P<0.05).The levels of adiponectin were negatively correlated with LDH during the therapy(r=-0.635, P=0.003), while leptin and resistin positively correlated(r=0.532, P=0.025 and r=0.637, P=0.012, respectively).Conclusion: Low adiponectin and high leptin, resistin are present at NHL diagnosis.Those adipocytokines alterations are progressively restored during the therapy.
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Key words:
- non-Hodgkin lymphoma /
- adiponectin /
- leptin /
- resistin
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