Abstract: Objective:To explore the effect of plasma cryoprecipitate in the subtotal thyroidectomy. Method:From January 2009 to June 2010, 200 cases of subtotal thyroidectomy were divided into two groups: experimental group including 100 cases with surgery preparation using plasma cryoprecipitate covering the wound, and hold drain observation and treatment, and control group including 100 cases with placing the hose or film drainage. The incidence of postoperative complications was observed, and multiple indexes were compared with the use of plasma cryoprecipitate preparation group.Result:The indicators of experimental group were better than those of control group. Conclusion:The plasma cryoprecipitate might have effect on improving bleeding and leakage in subtotal thyroidectomy, so there would no necessary to place drain, which would help reduce complications and patient suffering.