儿童原发性免疫性血小板减少症颅内出血的多中心临床研究

胡群; 刘爱国; 金润铭; 徐云云; 李建新; 李晖; 朱斌

儿童原发性免疫性血小板减少症颅内出血的多中心临床研究

- 1. 华中科技大学同济医学院附属同济医院儿科(武汉, 430030);
- 2. 华中科技大学同济医学院附属协和医院儿科;
- 3. 武汉市儿童医院血液科;
- 4. 襄阳市中心医院儿科

详细信息

通讯作者: 胡群,E-mail:qunhu0464@yahoo.com.cn

中图分类号: R554

收稿日期: 2012-08-24

Multi-center clinical study on intracranial hemorrhage in children with primary immune thrombocytopenia

- 1. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;
- 2. Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology;
- 3. Department of Hematology, Wuhan Children's Hospital;
- 4. Department of Pediatrics, Xiangyang Center Hospital

More Information

Corresponding author: HU Qun, E-mail: qunhu0464@yahoo.com.cn

Received Date: 24 August 2012

摘要

摘要: 目的：探讨我国儿童免疫性血小板减少症（ITP）颅内出血的发生率、相关临床因素及预后。方法：对四大儿童血液病中心2001-2011年收治的儿童ITP并发颅内出血者17例进行回顾性分析。结果：①ITP患儿颅内出血的发生率为0.46%。②颅内出血高危因素为急性患儿起病1个月内，慢性患儿病程1年后；并发感染、剧烈运动和外伤；血小板计数小于10×10⁹/L。③并发颅内出血者病死率为11.7%。④积极治疗后预后良好。结论：ITP患儿的颅内出血是一种可以通过积极治疗而达到有效治愈的疾病，幸存下来的患儿多数无严重的神经系统后遗症。
- 免疫性血小板减少症 /
- 儿童 /
- 颅内出血
Abstract: Objective: To explore the incidence, relevant clinical risk factors and prognosis of intracranial hemorrhage in children with primary immune thrombocytopenia (ITP).Method: Retrospective analysis was conducted on 17 cases of ITP with intracranial hemorrhage admitted in four children hematologic diseases centers during 2001 to 2011.Result: The incidence of intracranial hemorrhage in children with ITP was 0.46%.There were some risk factors for intracranial hemorrhage, such as disease course within 1 month for acute patients and longer than 1 year for chronic patients;concurrent-infection;strenuous exercise;trauma and platelet count less than 10×10⁹/L.The motality of ITP with intracranial hemorrhage was 11.7% and the prognosis was fine after active treatment.Conclusion: Intracranial hemorrhage in children with ITP was a disease which could be effectively cured through active treatment.The majority of survivors did not have severe neurological sequelae.
- primary immune thrombocytopenia /
- children /
- intracranial hemorrhage

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参考文献(9)

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