Combined detection value of antibodies against cyclic citrullinated peptide and rheumatoid factor in diagnosis of rheumatoid arthritis
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摘要: 目的：探讨联合检测抗环瓜氨酸肽抗体（抗CCP抗体）与RF在类风湿关节炎（RA）中的诊断作用。方法：采用电化学发光法检测抗CCP抗体，免疫比浊法检测RF。再采用EXCEL软件进行统计分析。结果：72例类风湿关节炎患者抗CCP抗体敏感性、特异性分别为40.2%、86.4%，RF的敏感性、特异性分别为90.2%、28.8%，二者敏感性及特异性比较，差异有统计学意义（P<0.05）。结论：抗CCP抗体对诊断RA与RF比较具有较高的特异性。但同时RF对诊断RA的敏感性较抗CCP抗体要高。因此抗CCP抗体检测在诊断自身免疫性疾病时具有较好的鉴别诊断意义，联合检测RF可以提高RA的早期诊断率。
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