dupMLL、HOX11和WT1基因阳性急性髓系白血病并发胸膜浸润1例并文献复习

王诗轩; 陈智超; 周浩; 吴秋玲

dupMLL、HOX11和WT1基因阳性急性髓系白血病并发胸膜浸润1例并文献复习

- 华中科技大学同济医学院附属协和医院血液病研究所(武汉, 430022)

详细信息

通讯作者: 吴秋玲,E-mail:wuqiuling@medmail.com.cn

中图分类号: R733.71

收稿日期: 2013-01-05

Acute myeloid leukemia with pleural invasion expressing dupMLL, HOX11, and WT1 genes: case report and literature review

- Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

More Information

Corresponding author: WU Qiuling, E-mail: wuqiuling@medmail.com.cn

Received Date: 05 January 2013

摘要

摘要: 目的：提高对伴dupMLL、HOX11 WT1基因阳性的急性白血病髓外浸润的认识。方法：报告1例伴dupMLL、HOX11和WT1基因阳性急性髓系白血病合并胸膜侵犯并对相关文献进行复习总结。结果：dupMLL、HOX11和WT1基因阳性急性髓系白血病患者易并发髓外浸润，髓外侵犯部位可同时表达融合基因。结论：伴dupMLL、HOX11、WT1基因阳性的急性白血病有较高的髓外浸润率并且对常规化疗耐药，预后较差。
- 白血病,髓系,急性 /
- dupMLL基因 /
- HOX11基因 /
- WT1基因
Abstract: Objective: In order to increase our understanding of acute myeloid leukemia with pleural invasion expressing dupMLL, HOX11, and WT1 genes.Method: One case of acute myeloid leukemia with pleural invasion expressing dupMLL, HOX11, and WT1 genes was reported and the literature was reviewed.Result: DupMLL, HOX11, and WT1 fusion genes may lead to high extramedullary infiltration where same genes were expressed.Conclusion: Acute myeloid leukemia patients expressing dupMLL, HOX11, and WT1 genes were accompanied by high extramedullary infiltration, resistance to routine chemotherapy, and poor prognosis.
- leukemia, myeloid, acute /
- dupMLL genes /
- HOX11 genes /
- WT1 genes

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参考文献(16)

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