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Abstract: Duffy antigen is involved in G protein-coupled receptor function in the form of chemokine receptors.The Fuff3 antigen of the Duffy system is expressed on the extracellular loop 3 which is a G protein-coupled receptor binding site.The G protein-coupled receptor of Duffy antigen is an important component of red blood cell immunity and is involved in various human immune functions,such as the invasion of red blood cells by Plasmodium,the proliferation of tumor cells,and the helper receptor for HIV virus to enter the cell.
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Key words:
- Duffy antigen /
- G protein-coupled receptor /
- chemokine /
- immune mechanism /
- plasmodium receptor /
- HIV viral receptor
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