人端粒保护蛋白1的结构与功能

黄璐; 胡丽华; 李一荣

人端粒保护蛋白1的结构与功能

- 华中科技大学同济医学院附属协和医院检验科(武汉, 430022)

详细信息

通讯作者: 胡丽华,E-mail:xhhlh@126.com

中图分类号: R997.1

收稿日期: 2012-09-09

Structure and function of human protection of telomere 1

More Information

Corresponding author: HU Lihua, E-mail: xhhlh@126.com

Received Date: 09 September 2012

摘要

- 人端粒保护蛋白1 /
- 端粒 /
- 端粒酶DNA
Abstract: Human protection of telomere 1(hPOT1),including two domains binding oligonucleotide and one domain interacting with TPP1,is an important subunit of telosome.hPOT1 binds double strands DNA directly,furthermore,it is associated with single strand DNA indirectly by interaction with TPP1.hPOT1 is an important factor for protecting the ends of telomere from DNA damage reaction,and maintaining stability of telomeric DNA length,chromosome and telosome.
- human protection of telomere 1 /
- telomere /
- telomerase DNA

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参考文献(29)

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