血浆置换治疗血栓性血小板减少性紫癜的疗效观察

金淑蓉; 徐凤娟; 叶宏辉; 金佩; 王静; 唐若腾; 金琪; 赵英

doi:10.13201/j.issn.1004-2806-b.2015.02.008

血浆置换治疗血栓性血小板减少性紫癜的疗效观察

- 金华市中心医院输血科(浙江金华, 321000)

详细信息

通讯作者: 金淑蓉,E-mail:jsyjsr@126.com

中图分类号: R554

收稿日期: 2014-07-02

Curative effect of plasma exchange treatment on thrombotic thrombocytopenic purpura

- Blood Transfusion Department, Jinhua Center Hospital, Jinhua, 321000, China

More Information

Corresponding author: JIN Shurong, E-mail: jsyjsr@126.com

Received Date: 02 July 2014

摘要

摘要: 目的:了解血浆置换治疗血栓性血小板减少性紫癜(TTP)的临床效果。方法:2011-2013年间确诊为TTP的10例患者进行血浆置换,每日1次,用新鲜冰冻血浆为置换液,每次2 000~3 000 ml,治疗2~5次,记录治疗前后血液检验相关指标和临床症状改善情况。结果:10例患者中2例死亡,8例存活。存活患者在经过3~5次血浆置换后,血小板、血红蛋白逐渐上升,尿素氮、间接胆红素、乳酸脱氢酶逐渐降低,治疗前后血液检验指标差异有统计学意义。结论:血浆置换是TTP的首选疗法,对TTP患者尽早的进行血浆置换可明显降低病死率,提高治疗效果。
- 血浆置换 /
- 血栓性血小板减少性紫癜
Abstract: Objective:To learn the efficacy of plasma exchange in treating thrombotic thrombocytopenic purpura(TTP). Method:Treating ten patients which were diagnosed as TTP in our hospital between 2011 and 2013 with plasma exchange, using fresh frozen plasma as replacement fluid, each time 2000~3000ml,1 time daily, for 2 to 5 days. Recording related indicators of blood test and the improvement of clinical symptoms before and after treatment. Result:In these 10 patients,2 patients died and eight patients survived. After plasma exchange 3 to 5 times, survivors' broken RBC in peripheral blood disappeared, platelet (PLT) and hemoglobin (Hb) increased gradually, and blood urea nitrogen (BUN), indirect bilirubin (IBIL) and lactate dehydrogenase (LDH) decreased gradually. The differences of blood test indicators before and after treatment were statistically significant. Conclusion:Plasma exchange would be the preferred treatment for TTP. Treating TTP patients with plasma exchange as soon as possible could reduce mortality significantly and improve the therapeutic effect.
- plasma exchange /
- thrombotic thrombocytopenic purpura

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参考文献(8)

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