Abstract: Objective: To analyze the infection status of syphilis among voluntary blood donors in Shijiazhuang area, in order to provide a scientific evidence for recruiting low-risk voluntary blood donators. Method: The gender, age and blood donation frequency of the syphilis-positive donators in Hebei Province Blood Center during 2011 to 2013 were investigated and statistically analyzed. The statistical method was χ² test performed by the SPSS 17.0 software. Result: In Shijiazhuang area, the positive rate of syphilis in female blood donors (0.388%) was higher than that in male blood donators (0.280%) with significant difference (χ²=37.929, P<0.01). The positive rate of syphilis in the donors for 18~25 years old, 26~35 year old, 36~45 year old and 46~55 year old were 0.246%, 0.308%, 0.357% and 0.457%, respectively, and the difference was statistically significant (χ²=66.906. P<0.01), and the positive rate had arising trend with the increasing age. The syphilis positive rate of the initial blood donors was higher than that of repeat blood donors (χ²=317.987, P<0.01). Conclusion: It should be conducted to strengthen the blood donation propaganda and consultation work, increase the recruitment in the low risk blood donators, and establish a fixed population for blood donation.