武汉献血人群巨细胞病毒IgG血液筛查可行性分析

毕昊; 李刚; 余琴; 姚妍怡; 裴皓

doi:10.13201/j.issn.1004-2806-b.2017.10.009

武汉献血人群巨细胞病毒IgG血液筛查可行性分析

- 1. 武汉血液中心(武汉, 430030);
- 2. 湖北省妇幼保健院优生遗传中心;
- 3. 湖北省新华医院麻醉科
基金项目:
武汉市卫计委重点科研项目(No:WG14A04)

武汉中青年医学骨干人才培养工程资助(武卫计[2013]35号)

详细信息

通讯作者: 李刚,E-mail:lgwuhanbloodcenter@163.com

中图分类号: R446.6

收稿日期: 2016-12-24

Research on feasibility of HCMV-IgG serologic screening in donated blood in Wuhan

- 1. Wuhan Blood Center, Wuhan, 430030, China;
- 2. Maternal and Child Health Hospital of Hubei Province;
- 3. Hubei Xinhua Hospital

More Information

Corresponding author: LI Gang, E-mail: lgwuhanbloodcenter@163.com

Received Date: 24 December 2016

摘要

摘要: 目的:通过调查武汉市无偿献血人群巨细胞病毒(HCMV)IgG阳性率,探讨HCMV-IgG血液筛查在我市的可行性。方法:随机抽取2015年6至12月采集的武汉市无偿献血者全血标本1 760份,采用ELISA方法检测血浆中HCMV特异性IgG,统计IgG阳性率,并进一步对献血者的性别、年龄、职业进行分组,统计各组的IgG阳性率。结果:武汉市无偿献血人群HCMV-IgG的总体阳性率为88.41%(95%CI:86.06%⁸9.99%)。不同性别、年龄及职业组的HCMV-IgG阳性率差异有统计学意义,但未发现具有较低HCMV-IgG阳性率的特殊群体。结论:从总体无偿献血人群中进行HCMV-IgG血液筛查的可行性不大,需要寻找具有较低HCMV-IgG阳性率的特殊群体以提高筛查效率。目前采用去白细胞血制品或者病毒灭活血制品可能是我市预防输血性巨细胞病毒感染的最适策略。
- 巨细胞病毒 /
- 献血者 /
- IgG /
- 血液筛查
Abstract: Objective:To investigate the current HCMV seroprevalence in blood donor population in Wuhan,and clear the feasibility of HCMV-IgG serologic screening of donated blood in Wuhan.Method:HCMV-IgG in 1 760 plasma samples from blood donors in Wuhan in 2015 categorized by sex,age and occupation were tested.Result:The prevalence of HCMV-IgG among the blood donors in Wuhan was very high,which was about 88.41%(95%CI:86.06%-89.99%).Although the results showed difference in the prevalence of HCMV-IgG by the categoricalanalysis of gender,age and occupation,finding of target group with low prevalence of HCMV-IgG failed.Conclusion:The prevention strategy of transfusion-transmitted CMV by serologic screening of donated blood for HCMV may be not suitable in Wuhan at present,waiting for the special donor groups with low prevalence of HCMV-IgG to be found in future.So some other strategies such as leukoreduction or virus inactivation may be more feasible,now.
- cytomegalovirus /
- blood donors /
- IgG /
- serologic screening

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