Abstract: Objective:To investigate the influence of acute normovolemic hemodilution with domestic hydroxyethyl starch on renal function in surgical patients with ectopic pregnancy.Method:A total of 72 cases of surgical patients with ectopic pregnancy were randomly divided into observation group and control group,36 cases in each group.Autologous blood was collected after anesthesia induction and before operation,then were infused isopyknic domestic and imported hydroxyethyl starch respectively in two groups.The autologous blood was infused back intraoperative and postoperative.Hemoglobin (Hb),hematocrit (Hct),RBC,prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)were determined before operation,before autologous blood transfusion and the end of operation in two groups.β₂-microglobulin(β₂-MG),blood urea nitrogen (BUN) and serum creatinine (Cr)were determined before operation,24 hand 48h after surgery in two groups.Result:① Compared with before operation,Hb and Hct were decreased (P<0.05) before autologous blood transfusion,the end of operation,and more obvious before autologous blood transfusion in two groups,but they were still within the normal range.Hb and Hct were no statistical difference (P>0.05) at each point in time in two groups.Compared with preoperative,PT,APTT and TT before autologous blood transfusion and the end of operation were no significant change (P>0.05)in two groups.② Compared with before operation,the level of β₂-MG,BUN and Cr were no significant change (P>0.05)at 24 h and 48h after surgery in two groups.The level of β₂-MG,BUN and Cr were no statistical difference (P>0.05) at each point in time in two groups.Conclusion:Acute normovolemic hemodilution with domestic hdroxyethyk starch would have little influence on renal function in surgical patients with ectopic pregnancy,and have high security.