Study on relationship between the ratio of blood collection volume to the total blood volume of blood donors and donation related vasovagal reaction
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摘要: 目的:调查研究献血者献血量占总血容量比率与献血相关血管迷走神经反应(DRVR)的关系,为合理选择献血者献血量提供参考建议。方法:统计大连市血液中心2013-01-2017-12在献血屋内献血的213 304人次,分析289人次发生DRVR献血者相关信息,排除怀疑心理因素诱发DRVR的献血者,调取剩余175人次献血者的献血量、身高、体重等信息计算献血量占总血容量的比率。结果:2013-2017年在献血屋中发生DRVR者289人次,发生率为0.14%,其中男150人次,女139人次(发生率为0.11%、0.18%),2组比较差异有统计学意义(P<0.01)。献血时年龄18~22岁88人次,23~55岁201人次(发生率为0.42%、0.10%),2组比较差异有统计学意义(P<0.01)。首次献血者152人次,重复献血者137人次(发生率为0.18%、0.11%),2组比较差异有统计学意义(P<0.01)。175例计算献血量占总血容量比率的献血者中比率<5%者3人次、5%~10%者70人次、>10%~15%者102人次,其中出现较严重的一过性意识丧失者5%~10%组12人次、>10%~15%组15人次(出现率为0.17%、0.15%),2组比较差异无统计学意义(P>0.05)。结论:为了预防DRVR的发生,应该对首次献血者、年轻的献血者做好心理上的辅导,并为献血者提供良好的献血环境。对于体重较轻、休息饮食不佳等的献血者,应对其进行评估,通过身高体重估算他们的总血容量,根据结果选择最合适的献血量。Abstract: Objective:To investigate the relationship between the ratio of blood collection volume to the total blood volume of blood donors and donation related vasovagal reaction,and analyze the results to provide reference suggestions for reasonable selection of blood donation. Method:A total of 213 304 whole blood donations in blood donation house were counted from January 2013 to December 2017.We analyzed 289 donation cases with donation related vasovagal reaction.Then we calculated the ratio of blood collection volume to the total blood volume use the information on blood collection volume,height,weight,that collected from 175 donors. Result:The vasovagal reaction rate was 0.14% among donors who donations in blood donation house from 2013 to 2017.Among the 289 blood donors who responded,150 were males and 139 were females(the incidence was 0.11% vs.0.18%).There was significant difference between the two groups(P<0.01).At the time of blood donation,there were 88 donors aged 18-22 and 201 donors aged 23-55(the incidence was 0.42% vs.0.1%).The difference between the two groups was significant(P<0.01).There were 152 first-time blood donors and 137 repeat blood donors(the incidence was 0.18% vs.0.11%).There was significant difference between the two groups(P<0.01).Among the 175 blood donors who calculated the ratio of blood collection volume to total blood volume,there were 3 person-times for the ratio less then 5%,70 person-times for the ratio of 5%-10%,and 102 persons-times for the ratio of 10%-15%.Among which the vasovagal syncope appeared,there were 12 donors in the 5%-10% group and 15 donors in the 10%-15% group(the rate of occurrence was 0.17% vs.0.15%).There was no significant difference between the two groups(P>0.05).Conclusion:In order to prevent the occurrence of donation related vasovagal reaction,psychological guidance should be given to the first-time donors and young donors,and we should provide a comfortable environment for blood donors.For low-weight donors,and donors who are lack of sleep,they should be calculated their estimated blood volume that takes into account sex,height,and weight,we should choose the most suitable blood collection volume based on the results.
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