徐州地区无偿献血者NAT检测情况及HBsAg-/HBV DNA+献血者流行病学分析

李艳; 赵艳梅; 时昌军; 史志旭

doi:10.13201/j.issn.1004-2806-b.2018.12.016

徐州地区无偿献血者NAT检测情况及HBsAg-/HBV DNA+献血者流行病学分析

- 徐州市中心血站(江苏徐州, 221006)

详细信息

通讯作者: 史志旭,E-mail:xzxzshizhixu@163.com

中图分类号: R457.1

收稿日期: 2018-06-25

Analysis of screening results by NAT and epidemiologic survey of volunteer blood donors with HBsAg-/HBV DNA+ in Xuzhou

- Xuzhou Blood Center, Xuzhou, 221006, China

More Information

Corresponding author: SHI Zhixu, E-mail: xzxzshizhixu@163.com

Received Date: 25 June 2018

摘要

摘要: 目的:探讨徐州地区无偿献血者运用核酸检测技术(NAT)检测及阳性献血者在该地区流行情况,为无偿献血者的动员和招募提供参考。方法:对2016-01-01-2017-12-31采集的经2种酶联吸附试验(ELISA)试剂检测合格及HBsAg、抗-HCV、HIV1+2抗体/抗原单试剂反应性献血者标本188 260例进行核酸检测,并对HBsAg-/HBV DNA+献血者进行流行病学分析。结果:187 791例ELISA阴性献血者中,共有194例HBsAg-/HBV DNA+献血者,阳性率为0.103%;139例HBsAg单试剂阳性标本中检出3例HBV DNA阳性。HBsAg-/HBV DNA+献血者阳性率男性明显高于女性,随年龄增长而增加,与学历水平呈负相关,学生和公司职员的阳性率较低。结论:徐州地区HBsAg-/HBV DNA+献血者阳性率总体较高,HBsAg-/HBV DNA+阳性分布呈现男性化、高龄化及低学历的流行病学特点,可以据此阳性分布特点进行无偿献血者动员与招募。
- 核酸检测 /
- 流行病学 /
- 无偿献血者
Abstract: Objective:To investigate the results of nucleic acid test and characteristics of infections from volunteer blood donors with HBsAg-/HBV DNA+ in Xuzhou area.Method:From January 2016 to December 2017,188 260 blood samples were assayed by routine ELISA and those with negative results or not tested reactive by one reagent of HBsAg/anti-HCV/anti-HIV1+2 of ELISA,were tested by nucleic acid amplification testing(NAT).HBsAg-/HBV DNA+ donors were conducted by epidemiologic analysis.Result:Out of 187 791 samples 194 were tested as HBsAg-/HBV DNA+ and with a positive rate of 0.103%;3 cases of HBV DNA were detected positive in 139 cases of single reagent HBsAg positive specimens.The positive rate of HBsAg-/HBV DNA+ donors in male donors was higher than those in female and rose with ages.The higher education level,the lower of the positive rate.Students and company employees had a lower positive rate.Conclusion:The rate of HBsAg-/HBV DNA+ of blood donors in Xuzhou occupied a great numbers of all donors.HBsAg-/HBV DNA+ donors showed an epidemiological distribution to masculinity,old aging and low academic qualification,which could be the evidence of mobilization and recruitment of blood donors.
- nucleic acid test /
- epidemiology /
- volunteer blood donors

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