Clinical study on coagulation function of premature infants of different gestational age after infusion of fresh frozen plasma
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摘要: 目的:探讨不同胎龄早产儿凝血功能及其在输注新鲜冰冻血浆后相关指标的变化情况。方法:随机选取实施输血治疗的102例住院早产患儿,按胎龄分为早期早产儿组(胎龄27~31＋6周,28例)、中期早产儿组(胎龄32~33＋6周,34例)和晚期早产儿组(胎龄34~36＋6周,40例)。分析各组输注新鲜冰冻血浆前后凝血指标的变化。结果:实施输血治疗的102例早产儿在输注新鲜冰冻血浆前后检测凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)的差异有统计学意义(P＜0.05),表现为PT、APTT缩短,FIB升高。中期早产儿组、晚期早产儿组输注新鲜冰冻血浆后PT、APTT均较早期早产儿组时长,FIB水平均较早期早产儿组低,差异有统计学意义(P＜0.05)。结论:早产儿凝血功能检测指标的参考范围明显异于成人,输注新鲜冰冻血浆可有效改善早产儿凝血功能。早期早产儿组较中期和晚期早产儿组的指标改善更为明显。Abstract: Objective:To investigate the changes of blood coagulation function of premature infants of different gestational age and related indicators after infusion of fresh frozen plasma.Method:A total of 102 inpatients with preterm labor who were treated with blood transfusion were randomly divided into early preterm infant group(27-31＋6 weeks,28 cases),intermediate preterm infant group(32-33＋6 weeks,34 cases)and late preterm infant group(34-36＋6weeks,40 cases)according to their gestational age.The changes of coagulation parameters before and after infusion of fresh frozen plasma were analyzed.Result:There were statistically significant differences in PT,APTT,TT and FIB before and after transfusion of fresh frozen plasma in 102 preterm infants treated with blood transfusion(P＜0.05),which showed that PT and APTT were shortened and FIB was increased.After infusion of fresh frozen plasma,PT and APTT of the two groups were longer than those of the early premature group,and FIB levels were lower than those of the early premature group(P＜0.05).Conclusion:The reference range of blood coagulation function of premature infants was obviously different from that of adults.Infusion of fresh frozen plasma can effectively improve blood coagulation function of premature infants.The improvement of the index of early preterm group was more obvious than that of middle term and late preterm group.
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Key words:
- premature infants /
- coagulation /
- gestational age /
- fresh frozen plasma
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