妊娠期糖尿病妇女血浆脂肪酸结合蛋白4水平与妊娠高血压和先兆子痫发生的关系

李园春; 马颖; 赵晶; 郭君丽

doi:10.13201/j.issn.1004-2806-b.2019.10.011

妊娠期糖尿病妇女血浆脂肪酸结合蛋白4水平与妊娠高血压和先兆子痫发生的关系

- 1. 宝鸡市妇幼保健院产科(陕西宝鸡, 721000);
- 2. 宝鸡市妇幼保健院妇科

详细信息

通讯作者: 郭君丽,E-mail:xghgjl@163.com

中图分类号: R714.24

收稿日期: 2019-03-04

Relationship between fatty-acid binding protein 4 and gestational hypertension and preeclampsia in women with gestational diabetes mellitus

- 1. Department of Obstetrics Baoji Maternal and Child Health Care Hospital, Baoji, 721000, China;
- 2. Department of Gynaecology, Baoji Maternal and Child Health Care Hospital

More Information

Corresponding author: GUO Junli, E-mail: xghgjl@163.com

Received Date: 04 March 2019

摘要

摘要: 目的:探讨妊娠期糖尿病(GDM)妇女血浆脂肪酸结合蛋白4(FABP4)水平与妊娠高血压和先兆子痫(GH/PE)发生的关系。方法:选择2014-01—2017-12住院治疗的50例GDM并发GH/PE患者纳入研究(GH/PE组),选择同期50例年龄、孕龄、妊娠前体质指数(BMI)相接近的GDM未并发GH/PE妇女患者作对照(非GH/PE组)。采用ELISA法检测患者血浆FABP4水平,并收集患者临床资料进行分组及统计学分析。结果:GH/PE组与非GH/PE组比较,2组血浆FABP4水平差异有统计学意义[(17.2±4.1)μg/L vs(11.6±3.3)μg/L,t=7.605,P=0.000]。所有入组患者中血浆FABP4水平与妊娠前BMI,孕中期BMI,孕龄,糖化血红蛋白(HbA1c),HOMA-IR,MAP呈正相关(r=0.241~0.582,均P＜0.05);非GH/PE组患者中血浆FABP4水平与妊娠前BMI,孕中期BMI,HOMA-IR呈正相关(r=0.341~0.611,均P＜0.05);GH/PE组患者中血浆FABP4水平与妊娠前BMI,孕中期BMI呈正相关(r=0.521,0.534,均P＜0.05)。多因素Logistic回归分析结果显示,血浆FABP4水平是影响GDM妇女GH/PE发生的危险因素(OR=1.212,95%CI 1.002~1.402,P=0.032)。结论:血浆FABP4水平在GDM并发GH/PE妇女中显著升高,可能与GDM女性GH/PE发生相关。
- 脂肪酸结合蛋白4 /
- 妊娠期糖尿病 /
- 妊娠高血压 /
- 先兆子痫
Abstract: Objective:To investigate the relationship between FABP4 and GH/PE in women with GDM.Method:50 patients of GH/PE in women with GDM in hospital from Jan 2014 to Dec 2017 were selected as the GH/PE group,50 women with GDM but without GH/PE,whose age,gestational age and pre-pregnancy BMI were similar,were selected as the non-GH/PE group.Plasma FABP4 levels were measured by ELISA,and other clinical data were collected for statistical analysis.Result:There was a significant difference in plasma FABP4 level between GH/PE group and non-GH/PE group[(17.2±4.1)μg/L vs(11.6±3.3)μg/L,t=7.605,P＜0.05].Plasma FABP4 levels in all patients were positively correlated with pre-pregnancy BMI,mid-pregnancy BMI,gestational age,HbA1c,HOMA-IR and MAP(r=0.241-0.582,all P＜0.05).The plasma FABP4 levels in non-GH/PE group were positively correlated with pre-pregnancy BMI,mid-pregnancy BMI and HOMA-IR(r=0.341-0.611,all P＜0.05).Plasma FABP4 levels in group GH/PE were positively correlated with pre pregnancy BMI and mid pregnancy BMI(r=0.521,0.534,all P＜0.05).Multivariate logistic regression analysis showed that plasma FABP4 was a risk factor for GH/PE in GDM women(OR=1.212,95%CI 1.002-1.402,P=0.032).Concluson:Plasma FABP4 level is significantly elevated in GDM women with GH/PE,and closely related to the occurrence of GH/PE in GDM women.
- fatty acid-binding protein 4 /
- gestational diabetes mellitus /
- gestational hypertension /
- preeclampsia

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