Abstract: Objective:To evaluate the implementation effects of retention and reentry strategies by statistical data on HIV.Method:Blood donor samples were tested for HIV by twice-HIV ELISA and nucleic acid test(NAT),and specimens of antibody reactive were sent to CDC for confirmation.Since 2015,blood donors who were previously ELISA(+)/NAT(-)but WB negative and had been shielded for 6 months could reenter to blood donors if their blood samples passed twice-HIV ELISA and NAT.Since 2016,the eligibility of blood donors could be retained if they were ELISA single positive while WB negative,and the donors could donate blood after 6 months.Result:A total of 589 072 specimens were collected from 2012 to 2018,with a total positive rate of 0.212‰.Altogether 451 were HIV ELISA reactive,26.39% of which were coincident with WB confirmation test.From 2015 to 2018,a total of 53 blood donors reentered and 60.38% of them donated blood after reentry,yielding a reactive rate of 6.25%.From 2016 to 2018,a total of 113 blood donors were retained and 19.47% of them donated blood afterwards,yielding a reactive rate of 18.18%.Six donors were confirmed negative by WB whose donation after retention or reentry were reactive.Conclusion:The HIV infection rate of blood donors in Nanjing is at a low level in the general population.In order to protect the rights and interests of blood donors,it can improve the efficiency of service for blood donors by implementing reentry strategy as well as reentry strategy especially for those false reactive HIV blood donors.However,there still exist certain reactive ones after retain or reentry,which calls for a further research on test strategy and process optimization.