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Abstract: The IN antigen is an antigen of the erythrocyte system,which has six antigens confirmed at present.Seventeen new exons were identified.The gene encoding product was adhesion molecule glycoprotein 44 and membrane differentiation antigen CD44.It can cause transfusion hemolysis and is an antigen of clinical significance.In antigen is one of the components of cytoskeleton protein,which participates in the formation of pseudopodia and cell migration.It has the function of adhesion of immune cells to tumor cells and is related to tumor metastasis.
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Key words:
- IN antigen /
- 17 exons /
- adhesion molecule glycoprotein 44 /
- transfusion reaction
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