Advances in research on Knops blood group system antigen
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关键词:
- Knops血型系统抗原 /
- 补体Ⅰ型受体(CR1) /
- 补体C3b/C4b受体 /
- 恶性肿瘤
Abstract: The gene of Knops antigen has 39 exons.The encoded product Kn antigen glycoprotein is composed of 1 920 amino acids.It is a complement C3b/C4b receptor,also known as complement type I receptor (CR1), which belongs to membrane differentiation antigen CD35.It is one of the important components of the immune mechanism.Among them,1 792 amino acids constitute 4 long homologous repeats,and Kn antigens are expressed in the 4th sequence (LHR-D). Kn antigen is associated with malaria parasite infection,leishmaniasis,bacterial infection,and insulin-dependent diabetes,malignant tumor,and AIDS. -
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