伴有MYC和BCL-6基因重排的弥漫性大B细胞淋巴瘤1例并文献复习

张凡; 李东; 环亚红; 周琛

doi:10.13201/j.issn.1004-2806.2014.01.022

伴有MYC和BCL-6基因重排的弥漫性大B细胞淋巴瘤1例并文献复习

- 明基医院血液科(南京, 210009)

详细信息

通讯作者: 李东,E-mail:linda.d.li@benqhospital.com

中图分类号: R733.4

收稿日期: 2013-05-07

MYC and BCL-6 gene rearrangement in diffuse large B cell lymphoma:a case report and review of literature

More Information

Corresponding author: LI Dong, E-mail: linda.d.li@benqhospital.com

Received Date: 07 May 2013

摘要

- 二次打击淋巴瘤 /
- 弥漫性大B细胞淋巴瘤 /
- MYC /
- BCL-6
Abstract: =Double-hit diffuse large B cell lymphoma (DLBCL) is a rare type of lymphoma with very bad prognosis even when patients receive high intensive chemotherapy or stem cell transplantation.Through a case of DLBCL with MYC and BCL-6 gene rearrangement,we discu
- double-hit lymphoma /
- diffuse large B cell lymphoma /
- MYC /
- BCL-6

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参考文献(18)

[1]	SAVAGE K J,JOHNSON N A,BEN-NERIAH S,et al.MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy[J].Blood,2009,114:3533-3537.
[2]	AUKEMA S M,SIEBERT R,SCHUURING E,et al.Double-hit B-cell lymphomas[J].Blood,2011,117:2319-2331.
[3]	COSTA L J,FELDMAN A L,MICALLEF I N,et al.Germinal center B (GCB) and non-GCB cell-like diffuse large B cell lymphomas have similar outcomes following autologous haematopoietic stem cell transplantation[J].Br J Haematol,2008,142:404-412.
[4]	FRIEDBERG J W.Double-hit diffuse large B-cell lymphoma[J].J Clin Oncol,2012,30:3439-3443.
[5]	LI S,LIN P,FAYAD L E,et al.B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21):an aggressive disease with heterogeneous histology,germinal center B-cell immunophenotype and poor outcome[J].Mod Pathol,2012,25:145-156.
[6]	SNUDERL M,KOLMAN OK,CHEN Y B,et al.B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma[J].Am J Surg Pathol,2010,34:327-340.
[7]	PILLAI R K,SATHANOORI M,VAN OSS S B,et al.Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive,frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas[J].Am J Surg Pathol,2013,37:323-332.
[8]	WAGNER S D,AHEARNE M,KO FERRIGNO P.The role of BCL6 in lymphomas and routes to therapy[J].Br J Haematol,2010,152:3-12.
[9]	MCDONNELL T J,KORSMEYER S J.Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)[J].Nature,1991,349:254-256.
[10]	JOHNSON N A,AL-TOURAH A,BROWN C J,et al.Prognostic significance of secondary cytogenetic alterations in follicular lymphomas[J].Genes Chromosomes Cancer,2008,47:1038-1048.
[11]	NIITSU N,OKAMOTO M,MIURA I,et al.Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations[J].Leukemia,2009,23:777-783.
[12]	LE GOUILL S,TALMANT P,TOUZEAU C,et al.The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement[J].Haematologica,2007,92:1335-1342.
[13]	THOMAS D A,O'BRIEN S,FADERL S,et al.Burkitt lymphoma and atypical burkitt or burkitt-like lymphoma:should these be treated as different diseases?[J].Curr Hematol Malig Rep,2011,6:58-66.
[14]	CORAZZELLI G,FRIGERI F,RUSSO F,et al.RD-CODOX-M/IVAC with rituximab and intrathecal liposomal cytarabine in adult Burkitt lymphoma and 'unclassifiable' highly aggressive B-cell lymphoma[J].Br J Haematol,2012,156:234-244.
[15]	CUCCUINI W,BRIERE J,MOUNIER N,et al.MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation[J].Blood,2012,119:4619-4624.
[16]	OHMACHI K,ANDO K,OGURA M,et al.Multicenter phase II study of bendamustine for relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma[J].Cancer Sci,2010,101:2059-2064.
[17]	SASAKI N,KURODA J,NAGOSHI H,et al.Bcl-2 is a better therapeutic target than c-Myc,but attacking both could be a more effective treatment strategy for B-cell lymphoma with concurrent Bcl-2 and c-Myc overexpression[J].Exp Hematol,2011,39:817-828.
[18]	SHORTT J,MARTIN B P,NEWBOLD A,et al.Combined inhibition of PI3K-related DNA-damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas[J].Blood,2013,121:2964-2974.