成人急性淋巴细胞白血病免疫表型特征及临床意义

陈琦; 朱雄鹏; 黄远玲; 苏密龙; 李碧玲; 吴立德; 杨建忠

doi:10.13201/j.issn.1004-2806.2015.03.013

成人急性淋巴细胞白血病免疫表型特征及临床意义

- 福建医科大学附属泉州第一医院血液科(福建泉州, 362000)

详细信息

通讯作者: 朱雄鹏,E-mail:xiongpengzhu@163.com

中图分类号: R733.71

收稿日期: 2014-07-30

Immunophenotype features and its clinical significance in adult acute lymphocytic leukemia

- Department of Hematology, the First Hospital of Quanzhou Affilited to Fujian Medical University, Quanzhou, 362000, China

More Information

Corresponding author: ZHU Xiongpeng, E-mail: xiongpengzhu@163.com

Received Date: 30 July 2014

摘要

摘要: 目的:探讨成人急性淋巴细胞白血病(ALL)细胞免疫表型特点及其对疗效的影响。方法:46例成人ALL初治患者,采用流式细胞术方法分析患者的免疫表型,然后给予标准诱导缓解方案(VDCLP方案)化疗,并观察其疗效。分析比较ALL伴髓系相关抗原(CD11b、CD13、CD14、CD15、CD33、CD117、cMPO)阳性患者与阴性患者之间的完全缓解(CR)率,HLA-DR表达情况及其与化疗后CR的关系。结果:46例ALL患者中,共有28例表达髓系相关抗原。伴髓系抗原表达阳性患者(My+ALL)CR率为78.6%,与伴髓系抗原表达阴性患者(My-ALL)CR率(83.3%)比较差异无统计学意义(P>0.05)。ALL患者HLA-DR+表达率为65.2%,HLA-DR+和HLA-DR-ALL患者CR率比较差异有统计学意义(70%:100%,P<0.05)。结论:ALL患者无论有无髓系抗原的表达其疗效无显著差异,但HLA-DR表达则明显降低化疗后CR率。
- 白血病,淋巴细胞,急性 /
- 免疫表型 /
- 临床意义
Abstract: Objective:To investigate the characteristics of immunophenotype in adult acute lymphocytic leukemia (ALL) and its relationship with treatment.Method:The immunophenotype of forty-six newly diagnosed adult patients with ALL were examined by indirect immunofluoresence method.All cases were treated with standard VDCLP chemotherapy regimen,and the curative effect was investigated.The difference of complete remission (CR) rates between myeloid antigen positive ALL (CD11b,CD13,CD14,CD15,CD33,CD117,cMPO) and myeloid antigen negative ALL was compared,and the relationship between HLA-DR and CR was analyzed.Result:Twenty-eight patients expressed medullary system antigens in 46 ALL.CR rate of patients with myeloid antigens expression was 78.6%,which was lower than 83.3% of patients without myeloid antigens expression,but there was no statistical significance(P>0.05).CR rate in HLA-DR+ALL was lower than that in HLA-DR-ALL,there was statistical significance between them (70% vs 100%,P<0.05).Conclusion:In adult ALL, there is no relevance between myeloid antigens expression and CR rate.But expression of HLA-DR is helpful to evaluate effect of induction chemotherapy.
- acute lymphocytic leukemia /
- immunophenotype /
- clinical significance

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参考文献(7)

[1]	张之南,沈悌.血液病诊断及疗效标准[M].3版,北京:科学出版社,2007:116-120.
[2]	Winslow ER,Brunt LM,Drebin JA,et al.Portal vein thrombosis after splenectomy[J].Am J Sure,2002,184:631-636.
[3]	胡群.急性淋巴细胞性白血病的MICM分型[J].实用儿科临床杂志,2008,23:1141-1142.
[4]	王翠翠,周春林,王慧君,等.成人急性淋巴细胞白血病的分型探讨[J].中华血液学杂志,2011,32(7):439-444.
[5]	庄红丽,孙慧,张秋堂.急性淋巴细胞白血病免疫分型与疗效分析[J].临床荟萃,2006,21(18):1321-1322.
[6]	宣柳,沈佐君,李筱青.双表型急性白血病的免疫分型[J].安微医科大学学报,2007,42(6):705-706.
[7]	丁才智.CD34、CD38和HLA-DR表达及其对急性白血病诊治的意义[J].检验医学与临床,2011,8(20):2502-2504.